ID A0A2K3DCS4_CHLRE Unreviewed; 1462 AA.
AC A0A2K3DCS4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Chloride channel protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHLRE_09g402051v5 {ECO:0000313|EMBL:PNW78323.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000313|EMBL:PNW78323.1, ECO:0000313|Proteomes:UP000006906};
RN [1] {ECO:0000313|EMBL:PNW78323.1, ECO:0000313|Proteomes:UP000006906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM008970; PNW78323.1; -; Genomic_DNA.
DR EnsemblPlants; PNW78323; PNW78323; CHLRE_09g402051v5.
DR Gramene; PNW78323; PNW78323; CHLRE_09g402051v5.
DR InParanoid; A0A2K3DCS4; -.
DR OrthoDB; 305929at2759; -.
DR Proteomes; UP000006906; Chromosome 9.
DR ExpressionAtlas; A0A2K3DCS4; baseline.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 2.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689:SF89; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR Pfam; PF00654; Voltage_CLC; 2.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006906};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 155..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 853..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 885..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 19..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1298..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..544
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..623
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1312
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1462 AA; 146128 MW; 9032C9F815BBEF0B CRC64;
MRTGEDRLLF QDMREYARFQ GTGGGGGRGG GGGGADRELD DLDDATDPLL GPGGGGGAGR
RRADLEGFGG GASLLLGGGA GGGDDGEGYV PWRRAWRSIF KKGNDVESAR VNHSFTPTER
AKLANVESID YLAPNSATYR KWLARQPHRR SWDRWVMMGS IGVATGLVAH GLYVLISFFA
GFKYGVTRWL LGHTNVGVAW LFNVVVSVGL VAASSAAVIG WAPEAQGSGV PEVMAYLNGC
MLPKLFNVAT LGVKWLSCGL VVASGLPVGP EGPLIHIGAA IGAALSQGHS TTMGFTTQLF
RRFRNPKDKR DFVTAGVSVG VAAAFNAPIG GLLFAFEEVA SFWQQRLGWQ VFYACMCSVL
TLNLSRSAGK ALLGQGSFGW FDKEVAFEQI GMSFSSHVLA VAPAAVIGLC AGLLAVIFTV
ANIKVTRLRA MLTGHLKWKR AIEPCALAAV YITGVMLLPL FFPCTPAECV VDAAGEMQCS
TGLNGPAGQG IPDMAPSLPL YTCRVIEHVT PNFTAVPAFP PPPSFPGAPS PPAAASPSFP
RPSPQEPDSA AFAPAFPPGL PPPPPAPTVP VDAFATPPLE PPFAPPPPLA PPSPPLAPAP
PTAPPAIPSP PLAPAPPPGL PPGHHHRRVL LASSTSTSTT SSSAAASADA DASGSANAAS
ALYYVTGGAS SQPVAGMAAA APAVSGRRYR AVPVGQGMGM GCGPQSHTFA NWGSRLGRRL
SESLLQQPLL QPPVLQPVLQ PHRSALGRAD GVAGAVSNDD SSSSSSSGAV GAGSSRTWLP
RGIPTGGGGS ITPNDDDDRR RGGGGGGGNG TSTVYYNQLA TLLFSTGEEG IKHLFARGTH
RLFGYKALLT MGAYYFVFAV LVAGSAVASG LFVPMLMIGA VLGRIFGLLT VDIAQGLGTR
WSVDTLGPWA WIDPGVFALV GAGAFMGGVT RMTVALAVIM IEVSSDVHML LPVLVAIMTA
KWVADAACHS LYHGLLEVKC VPFLPGEPVS AFSLDLLPVS HVMASPVVCL RQRMTIREIT
DVLRRCKHNG FPVLRDGPPP GSHVGGGGGA GGGGGGGGGA VGGAMPPLVP GPAGLVGPAS
AVFGPLGAGR AGSAAGAAGA GAGASGGVPG TCCGLITRQH LMVLLQKAVL AGRSDGLEVD
WTELNRKMMD PVAAARSVHQ QQMAVLAREM AADPALPTDS GLAALGLLRA AAAARGGSGG
GAAPPPAPPP GPSLSPAASA AAGLLSSLGL TGRGGSGGLG AYAALPGGSS GSGHAGQGGG
RSLEPAGAGA GVDNGPRFGG EGYDYGGVGV LPSVVPASEG MQPPPQLPPR GPGLQGPAVA
ARTRDGERLR LDDALARALN GPGGSGSGSH HSRHVYGGGS GRLLPSGAPA AASSAAAAAA
NGGAHAGNGV DAGIGAAAAA AVAGGAGGTA GGGGGGAAGV AGAGGMRVLA GRPGVTGGPT
ALHPTTAGMR NLLVSGNVPR LG
//
