ID A0A2K3DXJ2_CHLRE Unreviewed; 456 AA.
AC A0A2K3DXJ2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=BFN domain-containing protein {ECO:0000259|PROSITE:PS51658};
GN ORFNames=CHLRE_03g177450v5 {ECO:0000313|EMBL:PNW85238.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000313|EMBL:PNW85238.1, ECO:0000313|Proteomes:UP000006906};
RN [1] {ECO:0000313|EMBL:PNW85238.1, ECO:0000313|Proteomes:UP000006906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
CC -!- FUNCTION: Bifunctional nuclease with both RNase and DNase activities.
CC Involved in basal defense response. Participates in abscisic acid-
CC derived callose deposition following infection by a necrotrophic
CC pathogen. {ECO:0000256|ARBA:ARBA00025428}.
CC -!- SIMILARITY: Belongs to the VHL family. {ECO:0000256|ARBA:ARBA00010057}.
CC -!- SIMILARITY: Belongs to the bifunctional nuclease family.
CC {ECO:0000256|ARBA:ARBA00009095}.
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DR EMBL; CM008964; PNW85238.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K3DXJ2; -.
DR STRING; 3055.A0A2K3DXJ2; -.
DR PaxDb; 3055-EDP06110; -.
DR EnsemblPlants; PNW85238; PNW85238; CHLRE_03g177450v5.
DR Gramene; PNW85238; PNW85238; CHLRE_03g177450v5.
DR InParanoid; A0A2K3DXJ2; -.
DR OMA; ESHAWRF; -.
DR OrthoDB; 316848at2759; -.
DR Proteomes; UP000006906; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030891; C:VCB complex; IBA:GO_Central.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd05468; pVHL; 1.
DR Gene3D; 3.10.690.10; Bifunctional nuclease domain; 1.
DR Gene3D; 2.60.40.780; von Hippel-Lindau disease tumour suppressor, beta domain; 1.
DR InterPro; IPR036104; BFN_sf.
DR InterPro; IPR003729; Bi_nuclease_dom.
DR InterPro; IPR024053; VHL_beta_dom.
DR InterPro; IPR037140; VHL_beta_dom_sf.
DR InterPro; IPR036208; VHL_sf.
DR InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR PANTHER; PTHR15160:SF1; VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR; 1.
DR PANTHER; PTHR15160; VON HIPPEL-LINDAU PROTEIN; 1.
DR Pfam; PF02577; BFN_dom; 1.
DR Pfam; PF01847; VHL; 1.
DR SUPFAM; SSF103256; Hypothetical protein TM0160; 1.
DR SUPFAM; SSF49468; VHL; 1.
DR PROSITE; PS51658; BFN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006906}.
FT DOMAIN 253..396
FT /note="BFN"
FT /evidence="ECO:0000259|PROSITE:PS51658"
FT REGION 196..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 47498 MW; 06512082EDB54EDE CRC64;
MQGRCSLRVQ QRCRHGRIAG LRSVVLTCRL LSAARSVTSA ATPPAAGAGA PVAATQDASC
PLLAMPWSRR TALLGFSVLS GVALNLGGSG TAAAAPLLRS MGWTVESELT VLNDLEHPIK
IYWLNYDGDA ELFGSLNPGS VFTVKTYESH AWRFVDSSTG YTVAEHVAAA GQQVVRVASK
TGGVVAYTTA QSPGLAAPQQ RTLAGRGSGG AGLAQQEQLA APSATEPPRP LEPSSPAPPP
AAFEGFDGLG NDEAAYSLAQ LREVSIYPGG GNVLLLLPGS DTPLEVALAG PEALSLVAAT
GSLEQRRPST LGTWTRSLMA SGVEVRRVCI TRMVDGIFYS RIVLSRPNEP GGGSEAGASS
LCSLDATPGD SLSLALALRR PIYVNNEVVR LHRSVMDVFI RRREAMEAAA ASGVFDEAAE
AEADRAAQDA LDSITRAIPS APRAVHDLQL DHTLSA
//
