ID A0A2K3PT47_9HYPO Unreviewed; 1553 AA.
AC A0A2K3PT47;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=General negative regulator of transcription subunit 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=TCAP_07529 {ECO:0000313|EMBL:PNY18446.1};
OS Tolypocladium capitatum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX NCBI_TaxID=45235 {ECO:0000313|EMBL:PNY18446.1, ECO:0000313|Proteomes:UP000236621};
RN [1] {ECO:0000313|EMBL:PNY18446.1, ECO:0000313|Proteomes:UP000236621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 113982 {ECO:0000313|EMBL:PNY18446.1,
RC ECO:0000313|Proteomes:UP000236621};
RA Quandt C.A., Patterson W., Spatafora J.W.;
RT "Harnessing the power of phylogenomics to disentangle the directionality
RT and signatures of interkingdom host jumping in the parasitic fungal genus
RT Tolypocladium.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNY18446.1}.
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DR EMBL; NRSZ01001313; PNY18446.1; -; Genomic_DNA.
DR STRING; 45235.A0A2K3PT47; -.
DR OrthoDB; 1748at2759; -.
DR Proteomes; UP000236621; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16618; mRING-HC-C4C4_CNOT4; 1.
DR CDD; cd12438; RRM_CNOT4; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034261; CNOT4_RRM.
DR InterPro; IPR039780; Mot2.
DR InterPro; IPR039515; NOT4_mRING-HC-C4C4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12603; CCR4-NOT TRANSCRIPTION COMPLEX RELATED; 1.
DR PANTHER; PTHR12603:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF14570; zf-RING_4; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000236621};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 15..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 121..207
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 82..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..846
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..949
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1553 AA; 164266 MW; 2743BA2ED0F556D0 CRC64;
MASQDSFLDE EEDCCPLCIE EFDVYDRSFR PCPCGYQVCQ FCWNNIKTNM NGLCPACRRP
YDEKPTKWKV VTQEEVAQFN ANIQRSQRKR AQEQRQKEAQ KRETEKETRK SLVGVRVVQK
NLVYITGLAP TIREDELLKT LRKHEFFGQY GSIQKISISN RKSSDGQHHS LGIYVTFEKP
EEATRCIQAV HGSQNGDRIL KAQHGTTKYC SAWLKNEKCI NPGCMFLHEQ GEEEDSYTRQ
DLSSMNSIHT QRPLPGGAGT SSRSVSRQQV SQPTSPPASQ PMARSLSKEG SENGVDTSAL
PLSANWARNP QRSRRGSHAT SGAASSPAIS TSLPVTAEAV QEAVEDTASL ASTHAAAKAK
QSEGAASDER RRPTEDPELT ELLNAMGRLA MPKPDLELAN SLPPLFDMRG GAKRRAMREA
EKARVRDPED RSETHVPSDG EPEMGGGSLA LGGEPEEREV SADAHGFDQR QGGAQPPIQR
RSTDGLFGAA LGGSGFGQGP TNPMGRAMTP QQLASLRSQG GFGEQMPPGI SNHSNMFQTQ
GHNRQSSRFS FANDNPNSAT NVKLAANPRI MAQQSSMMPS SFQSQGGNXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXVA PPPGLKSTGT PPSMFGQSFG GSGFGAAPKD
SSNDLLQGYI GRSRGGGNPP HDAGKREYMI SSFSDQYPPP STSTPAPASG LLASLYGNHP
GAFQDFGSKQ KKKGKKHRHA NTSSSGGSGL VDLADPSILQ ARMQHQPQSN AGVGQGLFGG
GQSQDDELLS LDEATNSVDA LVSDEPRGVF ARPGLYSAMG AGPLAPPGFA APPGEPETPL
KPSTAPGRPR PANIVPVVPK IPPPGLDRGA VTPEQTPRKV APGSETRKNI KSLVVDSGLA
TTGLSQPRPG QLRAAIALQD EDFPALNAPK ARKQPPASPA IPAVPTPNGT PAPKKSSSDR
GSETATEKPN NNPAAAPTQP IESGHRKQGA GNPQPSKAAV SGAEDSIKTT GSADPSAVFP
FPPLLMPSAA RTTSPAPRAA PKTIRVMPTA RTEVALPSPA QSVASKAVST SYRPGTPGSE
INSDTASVLS ASVSASRAGS PPPSKIGSAA IRSTTKSQQR KQRKEATKQE TKTIAGAPKS
EAEEHAPVLG RKKKQKKEKS ATATTAQTRA DAPAQGPVKG EEPASAGAQK EDGRGKDSDD
ADLKAKATSI NKSAKGKEKE KEKEKSATVP SQPPPPETTS APQTAEPEKP QPGPVSVFAE
IRDSLWTTAV EALLMLRPVA SSSSRQDHGN NNAQSNKTGY CKDCACKCGE IHDDDLAALR
AGRPVRKQFH VDGSRMLITP NGDCIRGLTP EEEDAFLDLQ AAIAATAENP GAFVAPRHQP
GSGAFSLIKG RAVPNGRPNI FPATSQPQSQ DPIGKLQRED ALSYINQYVL PRLNLGASNM
GFPKGASPAR DSAAASLNSL APYFYGPDAA AGVGIYSAPD GARAMQDFAS SGVAQGDEAG
KMPGASGIGG IPLMSVEDAE MALTTARKET EKLEKGLNAV IKRNRRLLLG SGN
//
