ID A0A2K3QAR2_9HYPO Unreviewed; 2379 AA.
AC A0A2K3QAR2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 22-FEB-2023, entry version 14.
DE RecName: Full=THO complex subunit 2 {ECO:0000256|ARBA:ARBA00019596};
GN ORFNames=TCAP_05442 {ECO:0000313|EMBL:PNY24622.1};
OS Tolypocladium capitatum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX NCBI_TaxID=45235 {ECO:0000313|EMBL:PNY24622.1, ECO:0000313|Proteomes:UP000236621};
RN [1] {ECO:0000313|EMBL:PNY24622.1, ECO:0000313|Proteomes:UP000236621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 113982 {ECO:0000313|EMBL:PNY24622.1,
RC ECO:0000313|Proteomes:UP000236621};
RA Quandt C.A., Patterson W., Spatafora J.W.;
RT "Harnessing the power of phylogenomics to disentangle the directionality
RT and signatures of interkingdom host jumping in the parasitic fungal genus
RT Tolypocladium.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the THOC2 family.
CC {ECO:0000256|ARBA:ARBA00007857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNY24622.1}.
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DR EMBL; NRSZ01000864; PNY24622.1; -; Genomic_DNA.
DR STRING; 45235.A0A2K3QAR2; -.
DR OrthoDB; 179356at2759; -.
DR Proteomes; UP000236621; Unassembled WGS sequence.
DR GO; GO:0000347; C:THO complex; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR InterPro; IPR040007; Tho2.
DR InterPro; IPR021418; THO_THOC2_C.
DR InterPro; IPR021726; THO_THOC2_N.
DR InterPro; IPR032302; THOC2_N.
DR PANTHER; PTHR21597:SF0; THO COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR21597; THO2 PROTEIN; 1.
DR Pfam; PF11262; Tho2; 1.
DR Pfam; PF11732; Thoc2; 1.
DR Pfam; PF16134; THOC2_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000236621}.
FT DOMAIN 153..879
FT /note="THO complex subunit 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16134"
FT DOMAIN 881..956
FT /note="THO complex subunitTHOC2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11732"
FT DOMAIN 1245..1580
FT /note="THO complex subunitTHOC2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11262"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1599..2379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1599..1615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1665
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1666..1685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1729..1743
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1747..1828
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1866..1881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1894..1934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..2021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2104..2126
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2139..2155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2167..2181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2259..2285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2304..2379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2379 AA; 262956 MW; 1A59CEBF7DFE5437 CRC64;
MPAKRRRSDL PSGDGGRPSP HRPTDTSLAQ HDREDGGGRG GGRGRGYRGG FSRRDSNYGH
GRNGSSHHQN PQTQQNQQGQ HQHTPTPPRS APFSFQAQPP SPKQPKPPSS PVNVKQPAPS
PSAQKHPTSP VAMRPPPDAA QPTAPSTYYY ENLTDEKVRN WAERGRQEIM QHGIQSLEDV
DITELSSLFQ EFIHAVVEGR LDAADAGACV KAILGEETPD AVKDSEAFGS HSLFLDSLAI
VMDNDPGLYR PALREFLVAT GVSPALMREV LDAPLLQQLG LIRDNFTRLG VRQATNLLYR
QANYNLLREE SEGYSKLITE LFSTNSIPPP PPGKTFEKVK ALIGTFDLDV GRALDVTLDV
TAAVLIKQFK FFVKFLRTSS WWPSARFSDG SSYIGGLPVW ALPDYPQWNT SEEDEANNAR
LKLERDVAFW DRAREVHLAA FYELGGRRVT DRHSQQSQIT NGQDSEGAVA DAEQAWIRET
NTLPALGNRV AAQLLGFKLR FYNSDMRDKT DVLPANLLYL AALLIKIGFL SLTDLYPHLS
PADGDMERVR EAEAEKLQKE EREARGGQMN ALLMAGVLPQ GDDDNPMASN VSKRELPKKT
EAEQNKVAAE EDDRNRLPEP LEQKVALLTQ LLTIGAIPES LFILGRFPWI PEVFPDILER
IHRILHVSVD KVYTDSRPWP VNVVEFPTKN MPDVDQAGVP KGSVRLNRLP GKKIWRWPFP
DKYDTNENQN YRYYWDEWAD NVPVCQTVDD VFTLCGTFLN LSGVNIGKDE SLVSKLASIG
AKSLAVDKSD SNRARWQDLL RRLLLPALSH TKANASAASA VWELAKQYPL VARYAMYAEW
FEGSISRLPA MRTAFARSVS ETKATMKRVS LTNLSEMAKR LAKTSYASPG IVFKVAFEQL
EVYSNLIEAF VECAKYFTDL SYDVLVWSLL NSLGKSRSRT QEDHALTTSK WLQALSRFSG
KVFRRYSVLN PVPVLKYVDQ QLFLGNSTDL IILREFISVM GGLVAAADFT DYQILSMSGG
RWLRQHTLIR AQDKRFENVK SSGRLIQALS DSKLATRLLI NLAQYRQVSS YNIPEDEAHV
KYLSSIIDDS HQALIQYLDF LWSNLEPAAF DAIVPSIPEL INSFGLQTDL AFLIGRGSLA
HRMFPWQPVK NKKDTSQTRK PGVDKEGDVS MSDAKPQNAE TNGGATQETA ENEDHQVGAG
PAALANSTNP NPFKKPDDSS LSRTAFATLR PIIDSVQPAV RPEVWQKMTP ELYATFWALQ
LGDLCFPEDI YTKERNRIMG EWSALGKDRS DTSRWGMDRK AEKRKELMDV QGYLIDELAE
HCLRKAKWKF YLTKQFQTSF PDSSVKADSI SDVLLEQCFL PRVLLSPADA EYTYRFIKAL
HDCNAPVFKL MSLLDRLFNA NRLRTLIFTC TVREAEYLGR FLKLILDDLS RWHKNEPALD
EKAAKAAKAT VRLGAYDKEG KGPSDQPRLG FVLTVNEQGK PETFVEHAQF RDLLFRWHKN
LNTALKTCLG GSEWMHIRNA ITVLRAVLDH FPAVDFMATQ FAAQLQRIST SEASKKATPE
SEEGGRVDLS VAAQGAMSEL QKRKSKWVMV QAFRSNAVSS LERGGETTGA NNHGKAGGSH
SADKAPGARL RPTAPDFRPR VAKPAPNKTH ATEVEDGEVR DAKDAKGGSS SSTPSESLPL
KPSDSARDSS TRRDEASGPS RSSTPRSGPA QGRPDTRAHK LPDRPTHNLP SRPDVPIPGP
VPPERYGQSR GHERRDGRDS REPRGPRDGR DPREAWDARE PRPSDPDRLG RPREFPERRG
TDGPGDRVDL PPRPGQHRDA RGRVQDRHNE APVQPSGPPP AVNEPLEPAM NPERAALFVQ
DGPDRPTRGP EAERQARGRR PAPIEVMDVV NPDRVALMED RNDVHNSQNR LPRDDGRDRG
PRAPSPRRIT RHGPEHGPPT GGYDDRQGRP FPQDPRGPQD PRGPGRDPRD RSPLPGSNFR
SDWPGDRDAD RGAMDKMRDP PAFHRPGPRG PEPEHKMPHQ DQNYGRLNPV PSSSDIPSGP
RGRVRSATRG GHGAHSSAPG RPDGRFGGPE TPRAPSPDKL PPTGPASGRG RRGGYEHGAG
PATPSGPPTG PPTGPPTGPP TGPPTGPHLD RKRNFGPGPE IQTPTSTNTS PSAGVHPDRL
AQMGGASLPP PPSPSGPPPA GPHRHANAGD RHASGPRQAP SGGMGPSPAE PGVPMGPASS
TDRSRSGGGR RQLAGINYML QQAQAMPDMG RNNGPRGGQP RQLLGNSDAQ VLTGGSPTSI
PGQERQDVMW QEPANWGSTN GGDGAARREH RGERESRPDR PSRPSRRSSR ERERERSPRL
AREGEAKEHG EYRDRRSMGA EAGGKEQKRW ARLLRVDGS
//
