ID A0A2K3QDU1_9HYPO Unreviewed; 895 AA.
AC A0A2K3QDU1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Mechanosensitive ion channel protein {ECO:0000256|PIRNR:PIRNR017209};
GN ORFNames=TCAP_04365 {ECO:0000313|EMBL:PNY25697.1};
OS Tolypocladium capitatum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX NCBI_TaxID=45235 {ECO:0000313|EMBL:PNY25697.1, ECO:0000313|Proteomes:UP000236621};
RN [1] {ECO:0000313|EMBL:PNY25697.1, ECO:0000313|Proteomes:UP000236621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 113982 {ECO:0000313|EMBL:PNY25697.1,
RC ECO:0000313|Proteomes:UP000236621};
RA Quandt C.A., Patterson W., Spatafora J.W.;
RT "Harnessing the power of phylogenomics to disentangle the directionality
RT and signatures of interkingdom host jumping in the parasitic fungal genus
RT Tolypocladium.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|PIRNR:PIRNR017209}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|PIRNR:PIRNR017209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNY25697.1}.
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DR EMBL; NRSZ01000688; PNY25697.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K3QDU1; -.
DR STRING; 45235.A0A2K3QDU1; -.
DR OrthoDB; 1362946at2759; -.
DR Proteomes; UP000236621; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016688; MscS-like_plants/fungi.
DR PANTHER; PTHR31323; MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2; 1.
DR PANTHER; PTHR31323:SF1; MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2; 1.
DR PIRSF; PIRSF017209; Memb_At2g17000_prd; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR017209};
KW Membrane {ECO:0000256|PIRNR:PIRNR017209, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000236621};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 425..460
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..813
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 98510 MW; CF1E82FDD198FE1E CRC64;
MAPQLPDPMP SRHHSLTSRT SGFIPLSGGG RNDMDSGIPL TAVRSNSSTT GARKPIPGNS
TSFESSQSVN EKGELHNRHA GRRRRVGSLG RRGTGDTDEV KVNAMGRLYA RVVGFSVVTR
YMVYVVPIGL LLAVPLLVLP LTGHQNDIPV GSNNQDPKAP KMGPALFELF LWIEITWLTL
WAAKTVAWFL PRVFMFFCGI VSVGVRKYAT ILSNLTITLS LFFWALASWL TFRSLFQQAS
VNGIGWVQSL EQILGALFVS SGLLLGEKAI VQLISVSYHQ RSFANRIKAS KREVHLLGLL
YDASRTLFPM YCREFADEDH IINDSIEMML RKKAGSRMTG AAVPMRLIGD VGRFGDKVTS
AFGNIASEIT GKQVFNPNSA HSIVLEALEK RVSSEALGRR IWMSFVLEGK DALYVEDFRE
VLGPAYTNEA EEAFNAMDGD SNGDISLDEM VRKVIEVGKE RRAIGEGMKD IGQALRVFDK
VLLFVVFLLC IFVFFIFFRS SFVAVITSAG TTFLSLSFVF AVTTQEFLGS CIFLFVKHPY
DVGDRVDIGD KKMVVDKISL LYTVFTRIDI MQVVQASSLR TLTLAVPNIQ LNNLWVENVS
RSKAMVETFE LDVSYDTSFE DIELLRAEME KFVRSADNSR DFRPEFNISV GGVGHLDKMV
LYMSIKHKSN WHNDSVRATR RSKFMCALAV ALKKVPIYGP SGGTETLGGP TNPAYSVAVS
DQFASTARDE AAKKKEAGRM VPANGQTEEE GREAERHAIS EINTRSLAVD TADTRDDRSA
TSRDPSEGPR RSRDADSPGT EPLKQDVTRG RRKAGEGLQN LAPTESGPGG LPAHAASPHL
NAFDEEANTG MPSTFYSINR PAESRADGAL EEEKEALNPS ASHRGPHRGP SPGHR
//
