ID A0A2K3QI18_9HYPO Unreviewed; 326 AA.
AC A0A2K3QI18;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|ARBA:ARBA00020629, ECO:0000256|RuleBase:RU364141};
DE AltName: Full=Mediator complex subunit 4 {ECO:0000256|ARBA:ARBA00031257, ECO:0000256|RuleBase:RU364141};
GN Name=MED4 {ECO:0000256|RuleBase:RU364141};
GN ORFNames=TCAP_02908 {ECO:0000313|EMBL:PNY27163.1};
OS Tolypocladium capitatum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX NCBI_TaxID=45235 {ECO:0000313|EMBL:PNY27163.1, ECO:0000313|Proteomes:UP000236621};
RN [1] {ECO:0000313|EMBL:PNY27163.1, ECO:0000313|Proteomes:UP000236621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 113982 {ECO:0000313|EMBL:PNY27163.1,
RC ECO:0000313|Proteomes:UP000236621};
RA Quandt C.A., Patterson W., Spatafora J.W.;
RT "Harnessing the power of phylogenomics to disentangle the directionality
RT and signatures of interkingdom host jumping in the parasitic fungal genus
RT Tolypocladium.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364141}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNY27163.1}.
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DR EMBL; NRSZ01000452; PNY27163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K3QI18; -.
DR STRING; 45235.A0A2K3QI18; -.
DR OrthoDB; 2728817at2759; -.
DR Proteomes; UP000236621; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019258; Mediator_Med4.
DR PANTHER; PTHR13208; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR PANTHER; PTHR13208:SF2; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR Pfam; PF10018; Med4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364141};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW Reference proteome {ECO:0000313|Proteomes:UP000236621};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364141};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364141}.
FT REGION 122..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 326 AA; 36717 MW; 44ED20A272A119C0 CRC64;
MDKYIDERFE RLEKALSSLI DSVSKYHPST MQAEELKAAD TELSKGLEEV QTHQNNYLHI
QQLRQSSAAL DTQIRDTLTS LAATRKDIVT THTTTFPSEP NYPVAYEELL SYARRISKTT
MPPAATINAG GSPSPETQTP VPDSQPQSAM TPSARTPSQT QSPVANGMSQ QTATSMNTSL
PEGMSQYLNP LSGQLFFPWP LEDKIRSGSL ASYQILAEQG IDPKGYDPAT EVERKRQKEE
ERKANEEREK AEREEREKQI REERERLRIE RERQREKEQA EWRGASVAGG QPEAPGLARA
NTGVGEKKQF QFKNLDDLDD DDDDDD
//
