ID   A0A2K3QNT5_9HYPO        Unreviewed;      1195 AA.
AC   A0A2K3QNT5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=TCAP_00876 {ECO:0000313|EMBL:PNY29196.1};
OS   Tolypocladium capitatum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX   NCBI_TaxID=45235 {ECO:0000313|EMBL:PNY29196.1, ECO:0000313|Proteomes:UP000236621};
RN   [1] {ECO:0000313|EMBL:PNY29196.1, ECO:0000313|Proteomes:UP000236621}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 113982 {ECO:0000313|EMBL:PNY29196.1,
RC   ECO:0000313|Proteomes:UP000236621};
RA   Quandt C.A., Patterson W., Spatafora J.W.;
RT   "Harnessing the power of phylogenomics to disentangle the directionality
RT   and signatures of interkingdom host jumping in the parasitic fungal genus
RT   Tolypocladium.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|RuleBase:RU367072}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNY29196.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NRSZ01000143; PNY29196.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K3QNT5; -.
DR   STRING; 45235.A0A2K3QNT5; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000236621; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236621};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          69..327
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          771..1103
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1195 AA;  131014 MW;  9D1BB3E649003B3C CRC64;
     MADFRQLALE FVLENDQPKL SRIARKAASE IQTAAANTNP VARWVEAVQP WMPGSNDDDV
     MKDGQDAPDW TARAKALEFL SQTLDFLSND ALKPSQVKLL VAFFGAMFDV DHKAGIKASA
     TALSQIIAMK SFQPQDGQDI IRNVCALKDD FPRQVSKTRL AVYELLRSLI TDTAVAGDLH
     TRGGASGFMN DLLHLCQLER DPDCLMVWFD ILRFFMMEYS PSQEMLEEVY GSFKAYFPIT
     LPRASQSIVT ADELKLQLRK CFCATDRLAP LALPFLIGKL DQGDGVTVNV KVDVLRTIRA
     CIEDYSRPEQ SITPYVNRMW DSLKYEVRNG EIEDTIWATL EVLKAVTSRL KDEELRDYTL
     TVTRDCVNDL SNPTYAAAAG RLLISVLSAN PCAFVLMVAP ALTHIKENLR HPKSPMHSQD
     LFKILRIILE TRLLLTGVQM TDQERGDFAS VDSGFKNLYS DVYKKAVNLG STADPSYDDV
     KLSTEAVQGA GALVCQRIVT TTTTPESQAQ AYLLLPEGTC AEICDVLFSI ASQSRDGVTQ
     NTGSDELVNE SIQALQRSIQ AYPWGFRPLV ERGVAMTQKS YSNPSPESVA TIQRLCSALA
     YVGHLDLRQS LTNGMRNFLC LSRALARELL AAIDAKADPS IWSAFAGGIH SAALHFNDAC
     IELEPKEGLT MAPDLWLSGL VDKFPELSSI GATTNADAGS RDQLLVVPEA QRRVPDATSV
     AQLRNDGLLI TLYVCRLLYR RATKPLEAHP QTGKKALTLS DDFTGVDKSA EYRYLHQLSK
     LVDFVVYQMG SAGLSSPRME SYFLSLFRDD FISVPSSAPG GQQTAADDNS WNWLALGPLN
     VLSFGILKSL RPSGVARLYD IGVAQQILVN GTSSISGQSD SMVLPVTRAI MAALANKYKL
     EGLADLMTTL EQHLQSSLKQ ASTGSTPEDQ RSGLEQTLTS FTLAGGLLRR CTGKQTQGLL
     RLLREAPIDP TAGYRLAQGL EIIVAPQTHL NKGGGAVEKP LWMQKVYIDL AKPMIGSAAG
     ASPEVQNPLI KANYSIGVLQ MVKHMRFSIY EDDSNKIVRI AISVAQNMGA GPDAKAAVEV
     LKNILVEAPE QAQDHIRSLI TVCIGLFSIR ASSTQARPEW LPGGHAGSTY DPEIEAGCGK
     LALEIVGGLP RMFESRYLLA YAPQVQRELC IACGHRVRDV RRTARLARAA WSDVK
//