ID A0A2K3QQ52_9HYPO Unreviewed; 2126 AA.
AC A0A2K3QQ52;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Helicase SEN1 {ECO:0000313|EMBL:PNY29672.1};
GN ORFNames=TCAP_00416 {ECO:0000313|EMBL:PNY29672.1};
OS Tolypocladium capitatum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX NCBI_TaxID=45235 {ECO:0000313|EMBL:PNY29672.1, ECO:0000313|Proteomes:UP000236621};
RN [1] {ECO:0000313|EMBL:PNY29672.1, ECO:0000313|Proteomes:UP000236621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 113982 {ECO:0000313|EMBL:PNY29672.1,
RC ECO:0000313|Proteomes:UP000236621};
RA Quandt C.A., Patterson W., Spatafora J.W.;
RT "Harnessing the power of phylogenomics to disentangle the directionality
RT and signatures of interkingdom host jumping in the parasitic fungal genus
RT Tolypocladium.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNY29672.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NRSZ01000075; PNY29672.1; -; Genomic_DNA.
DR STRING; 45235.A0A2K3QQ52; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000236621; Unassembled WGS sequence.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18042; DEXXQc_SETX; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR024481; Helicase_Sen1_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF12726; SEN1_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:PNY29672.1};
KW Helicase {ECO:0000313|EMBL:PNY29672.1};
KW Hydrolase {ECO:0000313|EMBL:PNY29672.1};
KW Nucleotide-binding {ECO:0000313|EMBL:PNY29672.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000236621}.
FT DOMAIN 88..852
FT /note="Helicase Sen1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12726"
FT DOMAIN 1329..1623
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1630..1826
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1024..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..2034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2047..2067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1965..1980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2126 AA; 237314 MW; 256BAC3E6EB88038 CRC64;
MAEFNEDLGR WFDELQKIPA DHHLLCPKIS HDDEENYKSL DDLDTSISRD EKQARIQDAE
RRIEITYWNS LIFGFEKKHA GKWLEEFTTR LENSLKLCSD CVLNWHMKRK TQLHKFSERW
NEEAVSHIED LLNKLDVARI EHNIAWAKQY IEKIEASGAT FKKAQFGEHL PAVLISVYEA
LCCVPYIGAP DQRQLFQYVF MRLQGKSYLK LGTKDPLPGM TFFLMDTRIE DRLRWAQENW
KFIESTSMTE HQFDWAVGGG LVKGVDDVSK KDLSKLTSED YLDIERFWEG FECILRTLTG
QLIVSRLRSL EVRPGSLDIY DLLFRHIQFC RSEGVLVVAI RVLTSLLKKS PKAFWDVIGD
ARPNVIADLL FGSPVYKALL RQSLENCWSG FDSGSDGGVV PFPISWIHPW LDSLTRDRKY
DACEVLMHTL FETLARDASI GEPGQAACIR AGFDALRFTM KSFLDSETQI SSSTTHLYAS
AAFNLVAKNK DLILRNLQPS GEHHEGWTTF KVADAAKAVL YTAMKLDMKL VSEEFLAIHN
SKKLQSTVTR DSKAYWECLV EMFDASPDQV GLAKDILTCL GPLISVEQIR RPKNPKDGKL
GQLDPQLAAQ LEESIKVFNK ALEGIADVLV RVLGRISELD AAELSMLFAD RVSFQVIFGL
SVHDHEDLAE ASAEVLKSWT SERSRAASLE HMARLHPEQT LSSLISTLER VLQSPFPWGP
IRPLLTTSQD ILRGLADPSA GVLRTRALDP KLAAIVLRWW NEQWRFVSKS CRNIENWSLY
VQNRIMTDFC REIMELAEAL IAEDGLLTSV TACGRSDKDA MARILGPAKD NFRGMENMIR
LKDRWLVDVT VRVLCKILTR LRENNLEISA GPRKLITDAC VPTGTAREYT RTTNLNDRQR
AELLQALGYE EEVRIVQVCV PRAADGPRAK KQSKLDAWSR SATVNASSTA MPTRSNRDDV
LAMSKSIDSP ILKQVEARQA KARAKVPDAK GISALKESRQ REKLEKAKRD AEIIAKAKRL
RGETVPGEGS GIHGLGLTGK AHSRSEIMVN SSDEESDESD DSDADNQLAA LSTGGQKMLD
GQESMIQKHM RDGVRRPVKK ARQQRSVKEM RARLIPPMDR LHNTILAWDI FHGGSDPPDG
PAATEVATKY PDPRAYQQTF FPLLASEAWR AFVTAKDELT SQSFGMKIAS RASVDSFLEA
TFTMPVVLSR EQGLSEGDIL LVSQDESPLA APSAKHCLAR VHRITYKKDL VEITYRVASR
NNPLTLALTP GVSVHGIKIT NMTTIEREYA ALESLQYYDL MDEILKAEPS PIIRYGDERV
SNAMQNWALN RGQALAVLGA HENDGFTLIQ GPPGTGKTKT IVAMVGSLLS DQLAQAATGV
PVSAPPRPTN APNGTGQARS KKLLVCAPSN AAVDELVLRL KAGVTTISGK ARKINVLRLG
RSDAINVAVK DVTLDELVRA RLEGDNTRDK ARADREKLHE DAAKIKEELG LLRPRLEEAR
GLEDRAVYSG LSRQFEDLKR RQMDIGKMID ANKDSGNSIA REMEMRRRQV QQEILNSAHV
LCATLSGSGH EMFRNLEVEF ETVIIDEAAQ CVELSALIPL KYGCCKCILV GDPKQLPPTV
LSQSAARFGY DQSLFVRMQQ NHPRSVHLLD MQYRMHPEIS TFPSREFYEG QLRDGQDMLQ
LRQKPWHQSA LLGAYRFFDV QGVQQKGRRG QSLVNVKELE VAMQIYDTFS KKYQECDLTG
MIGIITPYKA QLHELRSRFK SRYGEGITDR IEFNTTDAFQ GRECEIIIFS CVRASATGGI
GFMTDIRRMN VGLTRAKSSL WILGDSRALV QGEFWRKLIH DARDRDRYTQ GDILSMLRRP
LEPARPGVFM PAPQAAVSKE VVMSDARGPG AMPRMTPGAT TAAAGLGGEM RTSSARRSSS
EVVPRSGAGP PVIHASAGKP PNAEQKKRPL DNAAPGQPGS KRVREAAEGN SHDERSNVHL
VGRRQTAQRT RGQVWPETEP PPRAPERPVS NVGVGADTSG AASSGDADSD SDESVEWIDV
VGQHAEQLGG KQQEAHGASS AEEAKTERLH AEEALTLAFG SMNHIVHRGW LHRGRHCKAL
ADCTKVQGST LGLHTRAHSD WDLYYD
//
