ID   A0A2K4ZCN0_9FIRM        Unreviewed;       519 AA.
AC   A0A2K4ZCN0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:SOY28225.1};
DE            EC=2.7.8.- {ECO:0000313|EMBL:SOY28225.1};
GN   Name=cls {ECO:0000313|EMBL:SOY28225.1};
GN   ORFNames=AMURIS_00932 {ECO:0000313|EMBL:SOY28225.1};
OS   Acetatifactor muris.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Acetatifactor.
OX   NCBI_TaxID=879566 {ECO:0000313|EMBL:SOY28225.1, ECO:0000313|Proteomes:UP000236311};
RN   [1] {ECO:0000313|EMBL:SOY28225.1, ECO:0000313|Proteomes:UP000236311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GP69 {ECO:0000313|EMBL:SOY28225.1};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; OFSM01000004; SOY28225.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K4ZCN0; -.
DR   OrthoDB; 9762009at2; -.
DR   Proteomes; UP000236311; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR   CDD; cd09154; PLDc_SMU_988_like_1; 1.
DR   CDD; cd09160; PLDc_SMU_988_like_2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   InterPro; IPR022924; Cardiolipin_synthase.
DR   InterPro; IPR027379; CLS_N.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR   PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR   PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR   Pfam; PF13091; PLDc_2; 2.
DR   Pfam; PF13396; PLDc_N; 1.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236311};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SOY28225.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        48..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          254..281
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          432..459
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   519 AA;  59930 MW;  E4A830A5BA4A1BB7 CRC64;
     MSIGEKVNTR LGAIKTVIYG RTAMILLGFL AQLIMLALGY ILLRNYSYLF YFLFLSISAV
     AVVYIFNAPD NPDTKLSWML PIAIFPVFGA IFYVTIVIQP GTKVLYNRLM YQAEHTKKYV
     LPRADTRDRL RTESPHMGQL AHYLENCDNS PVYDNTQVKY YALGDSQFVD MVEELKKAEK
     YIFMEFFIVA GGRMLGAILD ILLEKARQGV EVRFMYDGTN VLWNLPNDFP QMLEDEGIRC
     KMFAPIKPIF SPHYNNRDHR KILVVDGRVA FTGGINLADE YINEKERFGH WKDVGIMVRG
     DAVERFTYMF LEMWNESERE PDTREKYKLP SDASVSSDGY AIPYSVCPLG PERVGERVYL
     EIINTAHTYV HIMTPYLILD YQMLMALIYA AKRGVEIVII MPHIPDKKYA FVLAKTYYNQ
     LLESGVKIYE YEPGFVHAKV FVSDDVKAVV GTVNLDYRSL YHHFECGLIL YRNSEIAVIE
     KDVQDTLKKC MEMNTEDYKK MKLIDRALGR LMRIVAPLM
//