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Entry: A0A2K5ARX9_9ARCH
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ID   A0A2K5ARX9_9ARCH        Unreviewed;       526 AA.
AC   A0A2K5ARX9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=2-isopropylmalate synthase {ECO:0000256|ARBA:ARBA00012973};
DE            EC=2.3.3.13 {ECO:0000256|ARBA:ARBA00012973};
DE   AltName: Full=Alpha-isopropylmalate synthase {ECO:0000256|ARBA:ARBA00030312};
GN   Name=leuA {ECO:0000313|EMBL:SPC34401.1};
GN   ORFNames=NCAV_1234 {ECO:0000313|EMBL:SPC34401.1};
OS   Candidatus Nitrosocaldus cavascurensis.
OC   Archaea; Nitrososphaerota; Nitrososphaeria; Candidatus Nitrosocaldales;
OC   Candidatus Nitrosocaldaceae; Candidatus Nitrosocaldus.
OX   NCBI_TaxID=2058097 {ECO:0000313|EMBL:SPC34401.1, ECO:0000313|Proteomes:UP000236248};
RN   [1] {ECO:0000313|Proteomes:UP000236248}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCU2 {ECO:0000313|Proteomes:UP000236248};
RA   Kerou L M.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-
CC         isopropylmalate + CoA + H(+); Xref=Rhea:RHEA:21524, ChEBI:CHEBI:1178,
CC         ChEBI:CHEBI:11851, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00000064};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine
CC       from 3-methyl-2-oxobutanoate: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004689}.
CC   -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC       family. {ECO:0000256|ARBA:ARBA00006154, ECO:0000256|RuleBase:RU003523}.
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DR   EMBL; LT981265; SPC34401.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K5ARX9; -.
DR   KEGG; ncv:NCAV_1234; -.
DR   Proteomes; UP000236248; Chromosome ncav.
DR   GO; GO:0003852; F:2-isopropylmalate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
DR   CDD; cd07940; DRE_TIM_IPMS; 1.
DR   Gene3D; 1.10.238.260; -; 1.
DR   Gene3D; 3.30.160.270; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013709; 2-isopropylmalate_synth_dimer.
DR   InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011830; LEU1_arch.
DR   InterPro; IPR036230; LeuA_allosteric_dom_sf.
DR   InterPro; IPR000891; PYR_CT.
DR   NCBIfam; TIGR02090; LEU1_arch; 1.
DR   PANTHER; PTHR10277:SF9; 2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   Pfam; PF08502; LeuA_dimer; 1.
DR   SMART; SM00917; LeuA_dimer; 1.
DR   SUPFAM; SSF110921; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1.
DR   PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000313|EMBL:SPC34401.1};
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW   Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003523}.
FT   DOMAIN          21..272
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   526 AA;  57212 MW;  CAE177D74D55438A CRC64;
     MSSDVSNSIS NSDSSNSVDY VRIYDTTLRD GEQTPGVTLT PEDKLLIAIQ LDKLGVDVIE
     AGFPIVSQGE KEAVKMIVKQ GLNSEISVLA RTDKRDIDAA IDCGVRYVHT FIATSDIHLQ
     YKLKISREEA IRKAVDAIEY CKAHGLYVEF SAEDATRSDR EYLKQVYKAV VDAGADRIDV
     PDTVGYATPK YIHSLITELR STVKVPISIH CHDDFGLAVA NSIAAIEAGA ECAHVTINGL
     GERAGNASLE EFVMALHCLY NKRTRINTKL LYETSKLVAS LTGIIVQPNK AIVGENAFGH
     ESGIHTHGVL SNPLCYEPIS PELVGRKRWL EAGKHAGMHG IAAMLAEYGI RPEQEQLRQI
     VAKVKELGDK GKQVTDADLI AIASQVMNQQ NLVEHVRLMD FVVTTGINVV PTASVRLIID
     GKEYIVAETG VGPVDAALKA IQKITDRIAS IRLSEFRLEA ISGGSDALAE VSVKVEDSNG
     KISSARATGE DIVVASVQAM INGINKMMMK RTIDRDSNRE IQGYTV
//
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