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Database: UniProt
Entry: A0A2K5BUR8_AOTNA
LinkDB: A0A2K5BUR8_AOTNA
Original site: A0A2K5BUR8_AOTNA 
ID   A0A2K5BUR8_AOTNA        Unreviewed;       701 AA.
AC   A0A2K5BUR8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Lutropin-choriogonadotropic hormone receptor {ECO:0000256|ARBA:ARBA00022266, ECO:0000256|RuleBase:RU361222};
GN   Name=LHCGR {ECO:0000256|RuleBase:RU361222,
GN   ECO:0000313|Ensembl:ENSANAP00000000170.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000000170.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000000170.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for lutropin-choriogonadotropic hormone. The
CC       activity of this receptor is mediated by G proteins which activate
CC       adenylate cyclase. {ECO:0000256|RuleBase:RU361222}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU361222}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361222}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       FSH/LSH/TSH subfamily. {ECO:0000256|RuleBase:RU361222}.
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DR   RefSeq; XP_012320901.1; XM_012465478.1.
DR   AlphaFoldDB; A0A2K5BUR8; -.
DR   STRING; 37293.ENSANAP00000000170; -.
DR   Ensembl; ENSANAT00000001481.1; ENSANAP00000000170.1; ENSANAG00000001006.1.
DR   GeneID; 105726159; -.
DR   CTD; 3973; -.
DR   GeneTree; ENSGT00940000157364; -.
DR   OMA; TACIERD; -.
DR   OrthoDB; 1202285at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0038106; F:choriogonadotropin hormone binding; IEA:Ensembl.
DR   GO; GO:0035472; F:choriogonadotropin hormone receptor activity; IEA:Ensembl.
DR   GO; GO:0004964; F:luteinizing hormone receptor activity; IEA:Ensembl.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEA:Ensembl.
DR   GO; GO:0050890; P:cognition; IEA:Ensembl.
DR   GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
DR   GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR   GO; GO:0022602; P:ovulation cycle process; IEA:Ensembl.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0032962; P:positive regulation of inositol trisphosphate biosynthetic process; IEA:Ensembl.
DR   GO; GO:0090030; P:regulation of steroid hormone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0060065; P:uterus development; IEA:Ensembl.
DR   CDD; cd15359; 7tmA_LHCGR; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002131; Gphrmn_rcpt_fam.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002273; LSH_rcpt.
DR   PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24372:SF1; LUTROPIN-CHORIOGONADOTROPIC HORMONE RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF13306; LRR_5; 2.
DR   PRINTS; PR00373; GLYCHORMONER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01144; LSHRECEPTOR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU361222};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|RuleBase:RU361222};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361222};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU361222};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|RuleBase:RU361222};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU361222};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361222};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361222}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   CHAIN           26..701
FT                   /note="Lutropin-choriogonadotropic hormone receptor"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT                   /id="PRO_5014210715"
FT   TRANSMEM        366..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   TRANSMEM        399..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   TRANSMEM        485..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   TRANSMEM        528..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   TRANSMEM        574..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   TRANSMEM        608..628
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361222"
FT   DOMAIN          378..625
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   701 AA;  78807 MW;  DD2A7682FFDDE7D1 CRC64;
     MKQRLLALQL LKLLLLLPLP PLPRALREAR CCPEPCNCTP DGALRCPGPA AGLTRLSLAY
     LPVKVIPSQA FRGLNEVIKI EISQSDSLER IEANAFDNLL NLSEILIQNT KNLIHIEPGA
     FTNLPRLKYL SICNTGIRKF PDVTKIFSSE INFILEICDN LHITTIPGNA FQGMNNESIT
     LKLYGNGFEE VQSHAFNGTT VISLVLKENV HLERIHNGAF RGATGPSILD ISSTKLQALP
     SHGLESIQTL IATSSYSLKK LPSREKFVNL LDATLTYPSH CCAFRNVPTK EQNFSFSISK
     NFSKQCESTV RKQNNETLYP AIFAESEQSG WDYDYGFRLP KTPRCAPEPD AFNPCEDIMG
     YDFLRVLIWL INILAIMGNM TVLFVLLTSR YKLTVPRFLM CNLSFADFCM GLYLLLIASV
     DSQTKGQYYN HAIDWQTGSG CSTAGFFTVF ASELSVYTLT VITLERWHTI TYAIHLDQKL
     RLRHAILIML GGWLFSSLIA MLPLVGVSNY MKVSICFPMD VETTLSQVYV LTILILNVVA
     FIIICACYIK IYFAVRNPEL MATNKDTKIA KKMAILIFTD FTCMAPISFF AISAAFKMPL
     ITVTNSKVLL VLFYPINSCA NPFLYAIFTK TFRRDFFLLL GKFGCCKHRA ELYRRKDFSV
     YTSNYKNGFT GSNKPSQSTL KLSALHCQGT ALLDKTCYKE Y
//
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