ID   A0A2K5BWA3_AOTNA        Unreviewed;      1172 AA.
AC   A0A2K5BWA3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Folliculin interacting protein 2 {ECO:0000313|Ensembl:ENSANAP00000000709.1};
GN   Name=FNIP2 {ECO:0000313|Ensembl:ENSANAP00000000709.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000000709.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000000709.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the FNIP family.
CC       {ECO:0000256|ARBA:ARBA00007541}.
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DR   RefSeq; XP_012289269.1; XM_012433846.1.
DR   AlphaFoldDB; A0A2K5BWA3; -.
DR   STRING; 37293.ENSANAP00000000709; -.
DR   Ensembl; ENSANAT00000006146.1; ENSANAP00000000709.1; ENSANAG00000005809.1.
DR   GeneID; 105704543; -.
DR   CTD; 57600; -.
DR   GeneTree; ENSGT00390000009391; -.
DR   OrthoDB; 2725349at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:1990877; C:FNIP-folliculin RagC/D GAP; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042030; F:ATPase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:Ensembl.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR028086; FNIP_C_dom.
DR   InterPro; IPR026156; FNIP_fam.
DR   InterPro; IPR028085; FNIP_mid_dom.
DR   InterPro; IPR028084; FNIP_N_dom.
DR   PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR   Pfam; PF14638; FNIP_C; 1.
DR   Pfam; PF14637; FNIP_M; 1.
DR   Pfam; PF14636; FNIP_N; 1.
DR   PRINTS; PR02073; FOLLICULNIP1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          65..1163
FT                   /note="UDENN FNIP1/2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51836"
FT   REGION          132..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          635..721
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          938..958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..681
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        688..704
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        812..837
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        843..861
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1172 AA;  128363 MW;  29BF148369385F7A CRC64;
     MCGGTGKTTN QPGSWQDSAR CVSDAVPGVG KIYRALLCSK IKKHAGVDRS TDHTELNNSW
     SCSEFDLNEI RLIVYQDCER RGRQVLFDSK AVQKIEEVTA QKTEDIPIKI SAKCCQGSSS
     VSSSVSSSSS SLISSHSSSG GSSHHAKEQL PKYQYTRPAS DVNMLGEMMF GSVAMSYKGS
     TLKIHYIRSP PQLMISKVFS ARMGSFCGST NNLQDSFEYI NQDPNLGKLN TNQNSLGPCR
     TASNLGLLQA CSSKLLQGVA EGGPLRLTRS ASFFAAHSTP VDMPSRGQNE DRDSGIARSA
     SLSSLLITPF PSPSSSTSSS SSYQRRWLRS QTTSLENGII PRRSTDETFS LAEETCSSNP
     AMVRRKKIAI SIIFSLCEKE EAQRNFQDFF FSHFPLFESH MNRLKSAIEK AMISCRKIAE
     SSLRVQFYVS RLMEALGEFR GTIWNLYSVP RIAEPVWLTM MSSTLEKNQL CQRFLKEFTL
     LIEQINKNQF FAALLTAVLT YHLAWVPTVM PVDHPPIKAF SEKRTSQSVN MLAKTHPYNP
     LWAQLGDLYG AIGSPVRLTR TVVVGKQKDL VQRILYVLTY FLRCSELQEN QLTWSGNHGE
     GDQVLNGSKI MTALEKGEVE ESEYVVVTVR NEPALVPPIL PPTAAERQNP WPAEFPESPE
     GTDSRDLGLK PDKEAHRRPE QGPEACSTGY QEPASDSSWK PQNGFCGDEK NKEAPQDGSS
     RLSSCEVLGA GMKLDQQGIC ELCKVEMPTR LPDRSVAWPC PDRHLREKPP LEKVTFQIGS
     SASPESDLES RMKKMEERMK ACGPSLEARA ATDTAQDPQI SGSPFNPGFQ ENVCCPQNQP
     LEGDEGESDK GFAEDRGSRN EAVADAAGQL SHAADSDAAS AGAAGTRGRR LEAARGLYVK
     AAEGPVLEPV APRCVQRGPG LAAAAANIPC GDANKKANFR TEGDIPRNES SDSALGDSDD
     EACASAMLDL GHGTDRTGGS LEVELPLPRS QSVSTQNVRN FGRSLLAGYC PTYMPDLVLH
     GTSSDEKLKQ CLVADLVHTV HHPVLDEPIA EAVCIIADTD KWSVQVATSQ RKVTDNMKLG
     QDVLVSSQVS SLLQSILQLY KLHLPADFCI MHLEDRLQEM YLKSKMLSEY LRGHTRVHVK
     ELGVVLGIES NDLPLLTAIA STHSPYVAQI LL
//