UniProt: A0A2K5BYQ4

Database: UniProt
Entry: A0A2K5BYQ4_AOTNA

LinkDB:  A0A2K5BYQ4_AOTNA 
Original site:  A0A2K5BYQ4_AOTNA

All links

Ontology (57)   
   GO (57)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (9)   
   InterPro (4)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (71)   

Download RDF

ID   A0A2K5BYQ4_AOTNA        Unreviewed;       196 AA.
AC   A0A2K5BYQ4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=PYD and CARD domain containing {ECO:0000313|Ensembl:ENSANAP00000001569.1};
GN   Name=PYCARD {ECO:0000313|Ensembl:ENSANAP00000001569.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000001569.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000001569.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_012325379.1; XM_012469956.1.
DR   AlphaFoldDB; A0A2K5BYQ4; -.
DR   STRING; 37293.ENSANAP00000001569; -.
DR   Ensembl; ENSANAT00000014545.1; ENSANAP00000001569.1; ENSANAG00000013955.1.
DR   GeneID; 105729276; -.
DR   CTD; 29108; -.
DR   GeneTree; ENSGT00940000161873; -.
DR   OMA; PNTYSEV; -.
DR   OrthoDB; 4179218at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0097169; C:AIM2 inflammasome complex; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR   GO; GO:0008385; C:IkappaB kinase complex; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0072558; C:NLRP1 inflammasome complex; IEA:Ensembl.
DR   GO; GO:0072559; C:NLRP3 inflammasome complex; IEA:Ensembl.
DR   GO; GO:0140738; C:NLRP6 inflammasome complex; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0070700; F:BMP receptor binding; IEA:Ensembl.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:Ensembl.
DR   GO; GO:0017024; F:myosin I binding; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0032090; F:Pyrin domain binding; IEA:Ensembl.
DR   GO; GO:0005523; F:tropomyosin binding; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR   GO; GO:0044351; P:macropinocytosis; IEA:Ensembl.
DR   GO; GO:0002277; P:myeloid dendritic cell activation involved in immune response; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR   GO; GO:0032688; P:negative regulation of interferon-beta production; IEA:Ensembl.
DR   GO; GO:0044546; P:NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0002821; P:positive regulation of adaptive immune response; IEA:Ensembl.
DR   GO; GO:0002588; P:positive regulation of antigen processing and presentation of peptide antigen via MHC class II; IEA:Ensembl.
DR   GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR   GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
DR   GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
DR   GO; GO:2000406; P:positive regulation of T cell migration; IEA:Ensembl.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR   GO; GO:2001242; P:regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR   GO; GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR   CDD; cd08330; CARD_ASC_NALP1; 1.
DR   CDD; cd08321; Pyrin_ASC-like; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 2.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50824; DAPIN; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023233};
KW   Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          1..91
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          107..196
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
SQ   SEQUENCE   196 AA;  21775 MW;  7315A1904F8AE483 CRC64;
     MGRARDAILD ALENLTADEL KKFKLKLLSV PLREGYGRIP RGALLPMDAM DLTDKLVSFY
     LEAYGAELTA TVLRDMGLQE MAGQLQGATQ QGSGAAPAGI WAPPQPAAKP GQHFIDLHRA
     ALIARVTEVE GLLDALYGKV LTEEQYQAVR AERTNPTKMR KLFSFVPAWN WNCKDLFLQA
     LRETQSYLVE DLEQKS
//

DBGET integrated database retrieval system