ID A0A2K5C096_AOTNA Unreviewed; 1120 AA.
AC A0A2K5C096;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Integrin subunit alpha X {ECO:0000313|Ensembl:ENSANAP00000002120.1};
GN Name=ITGAX {ECO:0000313|Ensembl:ENSANAP00000002120.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000002120.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000002120.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A2K5C096; -.
DR Ensembl; ENSANAT00000017940.1; ENSANAP00000002120.1; ENSANAG00000016257.1.
DR GeneTree; ENSGT00940000154838; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF118; INTEGRIN ALPHA-X; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 20..1120
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5014210325"
FT TRANSMEM 1064..1086
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 21..78
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 151..329
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 443..503
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 506..564
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1120 AA; 122549 MW; 8A68971C3A9289B6 CRC64;
MTRTRAALLL FTALATSLGF NLDTEQPTAF RVDSAGFGDS VVQYANSWVV VGAPHEMTAA
NQTGGLYQCS YITGSCQPIG LQVPPEAVNM SLGLSLVATT SPSQLLACGP TVHHACGRNM
YLTGLCFLLS PAQLTQRLPA SMQECPRQEQ DIVFLIDGSG SISYNNFATM KSFVRAVMSH
FQRPSTQFSL MQFSSKFRTH FTFKEFRDSS NPLSLLASVY QLGGYTHTAT AIQKVVRELF
LASNGARRDA TKILIVITDG KKEGDWLDYD DVIPMADKAG IIRYAIGVGS AFQDRNSWKE
LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE MAQEGLSLGH
ADGPVLGAVG SFSWSGGAFL YPPNMNPTFI NMSQENVDMR DSYLGYSTQL ALWKGVQSLV
LGAPRYQHTG KAVIFTQVSG QWRMKAEVTG TQVGSYFGAS LCSIDMDSDG STDLILIGAP
HYYEQTRGGQ VSVCPLPRGW SRWWCNAVLR GEQGHPWGRF GAALTVLGDV NGDKLTDVAI
GAPGEEEDRG AVYLFPGYSG PSISPSYSQV RLDAFLSLQH ALSAGPDLCS GSYLARSPGL
RLSAGIPQPW TPGFLSLSTP SLRPPTGDLQ SSVTLDLALD PGRLSPRATF QETKSRSLSR
VQVLGLKTHC ENFDLLLPAC VEDSVTPITL RLNFTLVGKP LPYFRNLQPM LATDAQRYFT
ASLPFEKNCG ADHICQDDLG ISFSFPGLKT LLVGSNLELN AEVMVWNDGE DSYGTTITFS
HPAGLSYRHV AEGQKQGQLR SLRLTCDSAP AGSQGTWSTS CRINHLIFRE GAQISFLATF
DISPKAVLGD RLLLVANVSS ENNTPRTSKT TFQQELPVKY AVYTVASSHE QSTKYFNFSA
SEEKESRVAT HRYQVNNLGQ RDLPVSINFW VPVELNQEAV WTEVEVSHPQ DPSLRCSSEK
IAPPVSDFLA HIQKNPVLDC SIAGCLRFRC DVPSFSVQEE LDFTLKGNLS FGWVRQTSQK
KVSVVSVAEI TFDTSVYSQL PGQEAFMSAQ TMTVLENYEI HNPIPLIVGS SVGGLLLLAL
ITAALYKVGF FKRQYKEMME EANGQIAPEN RTSDPQPDNV
//