ID A0A2K5C0Q4_AOTNA Unreviewed; 1139 AA.
AC A0A2K5C0Q4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Sodium/potassium/calcium exchanger 1 {ECO:0000256|ARBA:ARBA00040585};
DE AltName: Full=Na(+)/K(+)/Ca(2+)-exchange protein 1 {ECO:0000256|ARBA:ARBA00042035};
DE AltName: Full=Retinal rod Na-Ca+K exchanger {ECO:0000256|ARBA:ARBA00042297};
DE AltName: Full=Solute carrier family 24 member 1 {ECO:0000256|ARBA:ARBA00042684};
GN Name=SLC24A1 {ECO:0000313|Ensembl:ENSANAP00000002249.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000002249.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000002249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR AlphaFoldDB; A0A2K5C0Q4; -.
DR Ensembl; ENSANAT00000018635.1; ENSANAP00000002249.1; ENSANAG00000016940.1.
DR GeneTree; ENSGT01030000234532; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008273; F:calcium, potassium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR004817; SLC24A1.
DR NCBIfam; TIGR00927; 2A1904; 1.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF36; SODIUM_POTASSIUM_CALCIUM EXCHANGER 1; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 976..1000
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1064
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1076..1097
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1109..1128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 604..745
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 978..1126
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 170..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..831
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..916
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 125627 MW; 24F235C505185F64 CRC64;
MRKLIRMGPQ ERRLLRTKRL HWSRLLFLLG MLIIGSTYQH LRRPRGLSSL WAAVSSHQPV
KLASRDLPSE EMMMVSSDPP KPSSEIGGEM LVPQASVGSD EATLSITVEN IPNMPKRTAK
MISTTTKNNY SPTAAGTERR KENTPTFSRT LTYYTTTSSR QIVKKYTPTT RGEMKSYSPT
QVSEKVKYTP SPHGRRVSTY APSTFMTMET SHAITPRTTV KDSDIMATYK ILETNSRKRM
EETTPTTLKG LVDSTPPYLT HEVETNVLTS PRNVVEKNNL TPPRRMENNS STHPWGLVGK
NNLMTQETVL AHTPATSEGQ VTISTMTGSS PAETKASTAA GSVRNPSPRT SVSAIETAPA
TVWRLAKKPS TAPSISATPM VRAKLTTQVH HCVVVKPTPA ITPPYLTHEV ETNVLTSPRN
VVEKNNLTPP RRMENNSSTH PWGLVGKNNL MTQETVLAHT PATSEGQVTI STMTGSSPAE
TKASTAAGSV RNPSPRTSVS AIETAPATVW RLAKKPSTAP SISATPMVRA KLTTQVHHCV
VVKPTPAMPT TLSPSLITAP LPEELSPSPS VLPSSLPDLH PKGEYPPDLF SVEERRQGWV
VLHIFGMMYV FVALAIVCDE YFVPALGVIT DKLQISEDVA GATFMAAGGS APELFTSLIG
VFISHSNVGI GTIVGSAVFN ILFVIGTCSL FSREILHLTW WPLFRDVSFY ILDLIMLILF
FLDSLIAWWE SLLLLLAYTF YVFTMKWNKH IEVWVKEQLS RRSAAKVMAL GNLSKMWLKA
ESTGEMTGEE CETVGEGETE EKSGGETQPE GEGETETQGK GAEHGDENEA EGNGDNEGEG
EGEIRTEDGE MKGNEGKTES QELGGENHGE AKNDEKDIED EGGSDGGDSK EEEKEEEEEE
EEEEEEEEEK KEKEEEEEEE EGRRREKRRR GRGGKPLSLD WPETRQKQAI YLFLLPIVFP
LWLTVPDVRR PESRKFFVLT FLGSIVWIAM FSYLMVWWAH QVGETIGISE EIMGLTILAA
GTSIPDLITS VIVARKGLGD MAVSSSVGSN IFDITVGLPV PWLLFSLING LQPVPVSSNG
LFCAIVLLFL MLLFVISSIA SCKWRMNKIL GFTMFLLYFV FLIISVMLED RIISCPVSV
//
