ID   A0A2K5C1F7_AOTNA        Unreviewed;       557 AA.
AC   A0A2K5C1F7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Cytokine-like nuclear factor N-PAC {ECO:0000256|ARBA:ARBA00034140};
DE   AltName: Full=Glyoxylate reductase 1 homolog {ECO:0000256|ARBA:ARBA00030287};
DE   AltName: Full=Nuclear protein NP60 {ECO:0000256|ARBA:ARBA00032038};
DE   AltName: Full=Putative oxidoreductase GLYR1 {ECO:0000256|ARBA:ARBA00034145};
GN   Name=GLYR1 {ECO:0000313|Ensembl:ENSANAP00000002543.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000002543.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000002543.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007598}.
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DR   AlphaFoldDB; A0A2K5C1F7; -.
DR   STRING; 37293.ENSANAP00000002543; -.
DR   Ensembl; ENSANAT00000019766.1; ENSANAP00000002543.1; ENSANAG00000017504.1.
DR   GeneTree; ENSGT00940000156435; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000786; C:nucleosome; IEA:Ensembl.
DR   GO; GO:0140463; F:chromatin-protein adaptor activity; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR   GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:Ensembl.
DR   GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IEA:Ensembl.
DR   CDD; cd05836; PWWP_GLYR1; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR035501; GLYR1_PWWP.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000313; PWWP_dom.
DR   PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
PE   3: Inferred from homology;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          32..92
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|Pfam:PF00855"
FT   DOMAIN          273..429
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          435..555
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   REGION          96..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..155
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..188
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   557 AA;  60964 MW;  F00A57DA3BEACDD6 CRC64;
     MAAVSLRLGD LVKWAAMLPA ILFPPFTLQI VNPPKDLKKP RGKKCFFVKF FGTEDHAWIK
     VEQLKPYHAH KEEMIKINKG KRFQQAVDAV EEFLRRAKGK DQTSSHNSAD DKNRRNSSEE
     RSRPNSGDEK RKLSLSEGKV KKNMGEGKKR VSSGSSERGS KSPLKRAQEQ SPRKRGRPPK
     DEKDLTIPES STVKGMMAGP MATFKWQPTA SEPVKDADPH FHHFLLSQTE KPAVCYQAIT
     KKLKICEEET GSTSIQAADS TAVNGSITPT DKKIGFLGLG LMGSGIVSNL LKMGHTVTVW
     NRTAEKCDLF IQEGARLGRT PAEVVSTCDI TFACVSDPKA AKDLVLGPSG VLQGIRPGKC
     YVDMSTVDAD TVTELAQVIV SRGGRFLEAP VSGNQQLSND GMLVILAAGD RGLYEDCSSC
     FQAMGKTSFF LGEVGNAAKM MLIVNMVQGS FMATIAEGLT LAQVTGQSQQ TLLDILNQGQ
     LASIFLDQKC QNILQGNFKP DFYLKYIQKD LRLAIALGDA VNHPTPMAAA ANEVYKRAKA
     LDQSDNDMSA VYRAYIH
//