ID A0A2K5C234_AOTNA Unreviewed; 612 AA.
AC A0A2K5C234;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Zinc finger protein 189 {ECO:0000313|Ensembl:ENSANAP00000002765.1};
GN Name=ZNF189 {ECO:0000313|Ensembl:ENSANAP00000002765.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000002765.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000002765.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_012322568.1; XM_012467145.1.
DR AlphaFoldDB; A0A2K5C234; -.
DR STRING; 37293.ENSANAP00000002765; -.
DR Ensembl; ENSANAT00000020258.1; ENSANAP00000002765.1; ENSANAG00000019063.1.
DR GeneID; 105727328; -.
DR CTD; 7743; -.
DR GeneTree; ENSGT00940000161823; -.
DR OrthoDB; 3081573at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 16.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR19818:SF162; ZINC FINGER PROTEIN 728-LIKE; 1.
DR PANTHER; PTHR19818; ZINC FINGER PROTEIN ZIC AND GLI; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 1..75
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 134..161
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 162..189
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 190..217
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 218..245
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 246..273
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 274..301
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 302..329
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 330..357
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 358..385
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 386..413
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 442..469
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 470..497
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 498..525
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 526..553
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 554..581
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 585..608
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 612 AA; 71424 MW; 217623A4722CA903 CRC64;
MASPSPPPEP KEEWDYLDPA QRSLYKDVMM ENYGNLVSLD VLNRDKDEEP TVKQEIEEIE
EEVEPQGVIV TRIKSEIDQD PMGRETFELV GRLDKQRGIF LWEIPRESLT QEQRMFRENT
NIIRKRPNSE EKCHKCEECG KGFVRKAHFI QHQRVHTGEK PFQCNECGKS FSRSSFVIEH
QRIHTGERPY ECNYCGKTFS VSSTLIRHQR IHTGERPYQC NQCKQSFSQR RSLVKHQRIH
TGEKPHKCSD CGKAFSWKSH LIEHQRTHTG EKPYHCTKCK KSFSRNSLLV EHQRIHTGER
PHKCGECGKA FRLSTYLIQH QKIHTGEKPF LCIECGKSFS RSSFLIEHQR IHTGERPYQC
KECGKSFSQL CNLTRHQRIH TGDKPHKCEE CGKAFSRSSG LIQHQRIHTR EKTYPYNETK
ESFDPNCSLV IHQEVYPKEK SYKCDECGKT FSVSAHLVQH QRIHTGEKPY LCTVCGKSFS
RSSFLIEHQR IHTGERPYLC RQCGKSFSQL CNLIRHQGVH TGNKPHKCDE CGKAFSRNSG
LIQHQRIHTG EKPYKCEKCD KSFSQQRSLV NHQKIHAEVK AQETHECDAC GEAFNCRISL
IQHQKLHTVW MQ
//
