ID A0A2K5C2S3_AOTNA Unreviewed; 239 AA.
AC A0A2K5C2S3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Insulin-like growth factor-binding protein 1 {ECO:0000256|ARBA:ARBA00013675};
GN Name=IGFBP1 {ECO:0000313|Ensembl:ENSANAP00000002995.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000002995.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000002995.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC have been shown to either inhibit or stimulate the growth promoting
CC effects of the IGFs on cell culture. They alter the interaction of IGFs
CC with their cell surface receptors. Promotes cell migration.
CC {ECO:0000256|ARBA:ARBA00025468}.
CC -!- SUBUNIT: Binds equally well IGF1 and IGF2.
CC {ECO:0000256|ARBA:ARBA00011863}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_012313979.1; XM_012458556.1.
DR AlphaFoldDB; A0A2K5C2S3; -.
DR STRING; 37293.ENSANAP00000002995; -.
DR Ensembl; ENSANAT00000020587.1; ENSANAP00000002995.1; ENSANAG00000019387.1.
DR GeneID; 105721484; -.
DR CTD; 3484; -.
DR GeneTree; ENSGT00940000157394; -.
DR OMA; QPWHCAP; -.
DR OrthoDB; 5394492at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:Ensembl.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:Ensembl.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022322; IGFBP1.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF6; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01977; IGFBPFAMILY1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..239
FT /note="Insulin-like growth factor-binding protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014426592"
FT DOMAIN 27..105
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 153..231
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
SQ SEQUENCE 239 AA; 26406 MW; 60E67ED281FA694A CRC64;
MLEVLAAGVW PVLLLLTAQV TAGARWQCEP CPPEKLTNCD PVPDTCLEVT RYASCDCCPV
CALTLGESCG VKTARCARGL TCQPLPGEKK PLRSLILGKG VCIQKSAKAE ATDDTDTFGE
ELMENSHRPA SSIQDRSMAD GRTDIEITNN NSKEPCRREL YRVLDNLAKI EESTGERVYR
FYLPNCNKNG FYHPKQCESA LDGGPRLCWC VYPWNGKRIP GSPESRVDPD CDLYVNAQN
//
