ID A0A2K5C2X0_AOTNA Unreviewed; 670 AA.
AC A0A2K5C2X0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN22 {ECO:0000313|Ensembl:ENSANAP00000003035.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000003035.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000003035.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00034734}.
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DR AlphaFoldDB; A0A2K5C2X0; -.
DR Ensembl; ENSANAT00000020630.1; ENSANAP00000003035.1; ENSANAG00000019287.1.
DR GeneTree; ENSGT00940000160958; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR047170; PTN12/18/22.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR45983; TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45983:SF1; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 24..124
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 121..152
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 210..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 75205 MW; FE935DD2E71C77DA CRC64;
MDQREILQKF LDEAQNKKIN KEELANEFML KRQSTKYKAD KTYPTTVAEK PKNIKKNRYK
DILPYDYSRV DLSLITSDED SSYINANFIK GAYGPKAYIA TQGPLSTTLL DFWRMIWEYS
VLIIPENFSV FSLIQEMRTQ RPSLVQTQEQ YELVYNAVLE LFKRQMDVIS NKHSGTESQA
KYSIPEQNHT LQADSYSPNL PKSTIKAAKM IDQKSKQRTE KESTESSSFD LRTSEKSAEE
ELVLHPTKSS TSFDFLELNY GFNKNADTTM KWQTKAFPTV GEPLQKHQSL DLGSILFEAC
SNSKPVNAAG RYFNSKVPIT RTKSTPFELI QQRETKEVDS NENFSYLESQ PQDSCFVKMQ
AQKVMHVSSA ELNYALPYES KHQVCNASNV KHCDCSAFGV YSYISLVEDP YFSTLPPSGT
GSKMSLDLPE KQDGTVLPCS LLPTSSTSLF SCYNSHDSLS LNSPTNIPPL LNQESAVVAT
APRIDDEIPP PLPVRTPESF IVVEETGEFS PNVPKSLSSA VKVKIGTSLE WGGTSGPKKF
DDSVRLRQSK SVKFRSPKSE LHQDCSSPPP PLPERTLESF ILADEDCMQA QSIETYSTSC
PDTMENSASS KQTLKTPGKS FTRSKSLKIL RNMKKSICNS CPPNKPAESV QSNNSSSFLN
FGMCVILRKS
//