ID A0A2K5C3V6_AOTNA Unreviewed; 367 AA.
AC A0A2K5C3V6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Protein NDRG2 {ECO:0000256|ARBA:ARBA00015427, ECO:0000256|RuleBase:RU367129};
GN Name=NDRG2 {ECO:0000313|Ensembl:ENSANAP00000003375.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000003375.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000003375.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC Down-regulates CTNNB1-mediated transcriptional activation of target
CC genes. May be involved in neuron differentiation.
CC {ECO:0000256|RuleBase:RU367129}.
CC -!- SUBCELLULAR LOCATION: Cell projection, growth cone
CC {ECO:0000256|ARBA:ARBA00004624}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU367129}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000256|ARBA:ARBA00005598,
CC ECO:0000256|RuleBase:RU367129}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5C3V6; -.
DR Ensembl; ENSANAT00000021007.1; ENSANAP00000003375.1; ENSANAG00000019531.1.
DR GeneTree; ENSGT00950000182872; -.
DR OMA; KTCFQPL; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF17; PROTEIN NDRG2; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367129};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367129};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU367129};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|RuleBase:RU367129};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU367129}.
FT REGION 330..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 40343 MW; 12BBC0565100DDAF CRC64;
MENGGSRQAT MAELQEVQIT EEKPLLPGQT PEAAKTHSVE TPYGSVTFTV YGTPKPKRPA
ILTYHDVGLN YKSCFQPLFQ FADMQEIIQN FVRVHVDAPG MEEGAAVFPL GYQYPSLDQL
ADMIPCILQY LNFSTIIGVG VGAGAYILSR YALNHPDTVE GLVLINIDPN AKGWMDWAAH
KLTGLTSSIS EMILGHLFSQ EELSRNSELI QKYRNIITHA PNLDNIELYW NSYNNRRDLN
FERGGDITLK CPVMLVVGDQ APHEDAVVEC NSKLDPTQTS FLKMADSGGQ PQLTQPGKLT
EAFKYFLQGM GYMASSCMTR LSRSRTASLT SAASIDGNRS RSRTLSQSSE SGTLSSGPPG
HTMEVSC
//