ID A0A2K5C4Y4_AOTNA Unreviewed; 722 AA.
AC A0A2K5C4Y4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Forkhead box K1 {ECO:0000313|Ensembl:ENSANAP00000003747.1};
GN Name=FOXK1 {ECO:0000313|Ensembl:ENSANAP00000003747.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000003747.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000003747.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A2K5C4Y4; -.
DR STRING; 37293.ENSANAP00000003747; -.
DR Ensembl; ENSANAT00000021433.1; ENSANAP00000003747.1; ENSANAG00000019885.1.
DR GeneTree; ENSGT00940000159507; -.
DR OMA; QTHDPRK; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071889; F:14-3-3 protein binding; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0061621; P:canonical glycolysis; IEA:Ensembl.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:Ensembl.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR GO; GO:0042594; P:response to starvation; IEA:Ensembl.
DR CDD; cd20054; FH_FOXK1; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047394; FH_FOXK1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF4; FORKHEAD BOX PROTEIN K1; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 112..164
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 294..389
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 294..389
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 35..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 74897 MW; D37BB5F295192213 CRC64;
GRSRRSSGPS ALLAATLGGP AAPVLCAAAA AAASSRGRAP PAPAQPTAAA PPLPLASERP
IAGRASGASG RARAATALVA ADGRARFAAS PGPALARLEG REFEFLMRQP SVTIGRNSSQ
GSVDLSMGLS SFISRRHLQL SFQEPHFYLR CLGKNGVFVD GAFQRRGAPA LQLPKQCTFR
FPSTAIKIQF TSLYHKEEAP ASPLRPLYPQ ISPLKIHIPE PDLRSMVSPI PSPTGTISVP
NSCPASPRGA GSSSYRFVQN VTSDLQLAAE FAAKAASEQQ ADTSGGDSPK DESKPPFSYA
QLIVQAISSA QDRQLTLSGI YAHITKHYPY YRTADKGWQN SIRHNLSLNR YFIKVPRSQE
EPGKGSFWRI DPASEAKLVE QAFRKRRQRG VSCFRTPFGP LSSRSAPASP THPGLMSPRS
SGLQTPECLS REGSPVPHDP DFGSKLASVP EYRYSQSAPG SPVSTQPVIM AVPPRPSSLV
AKPVAYMPAS IVTSQQPTGH AIHVVQQAPT VTMVRVVTTS ASSANGYILT SQGSAGSSHD
AAGAAVLDLG SEARGLEEKP TIAFATIPAA SGVIQTVASQ MAPGVPGHTV TILQPATPVT
LGQHHLPVRA VTQNGKHAVP TNSLAGNAYA LTSPLQLLAA QASSSSPVVV TRVCEVGAKE
PAAAVAATAT TTPATATTAS ASASSTGEPE VKRSRVEEPS GTATTPAGVI AAAGPQGLGT
GE
//
