ID   A0A2K5C524_AOTNA        Unreviewed;      1243 AA.
AC   A0A2K5C524;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN   Name=DCTN1 {ECO:0000313|Ensembl:ENSANAP00000003765.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000003765.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000003765.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00011010}.
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DR   AlphaFoldDB; A0A2K5C524; -.
DR   Ensembl; ENSANAT00000021455.1; ENSANAP00000003765.1; ENSANAG00000019488.1.
DR   GeneTree; ENSGT00940000155378; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR022157; Dynactin.
DR   PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR   PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR   Pfam; PF01302; CAP_GLY; 1.
DR   Pfam; PF12455; Dynactin; 1.
DR   SMART; SM01052; CAP_GLY; 1.
DR   SUPFAM; SSF74924; Cap-Gly domain; 1.
DR   PROSITE; PS00845; CAP_GLY_1; 1.
DR   PROSITE; PS50245; CAP_GLY_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          48..90
FT                   /note="CAP-Gly"
FT                   /evidence="ECO:0000259|PROSITE:PS50245"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          916..1007
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1243 AA;  137957 MW;  72220A0BBB4051F6 CRC64;
     MAQSKRHMYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV
     ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRG
     NNHPLTTTTR RPKPTRPAST GAAGASSSLG PSGSASAGEL SSSEPSTPAQ TPLAAPIIPT
     PALTSPGAAP PLPSPSKEEE GLRAQVRDLE EKLETLRLKR AEDKAKLKEL EKHKIQLEQV
     QEWKSKMQEQ QADLQRRLKE ARKEAKEALE AKERYMEEMA DTADAIEMAT LDKEMAEERA
     ESLQQEVEAL KERVDELTTD LEILKAEIEE KGSDGAASSY QLKQLEEQNA RLKDALVRMR
     DLSSSEKQEH VKLQKLMEKK NQELEVVRQQ RERLQEELSQ AESTIDELKE QVDAALGAEE
     MVEMLTDRNL NLEEKVRELR ETVGDLEAMN EMNDELQENA RETELELREQ LDMAGARVRE
     AQKRVEAAQE TVADYQQTIK KYRQLTAHLQ DMNRELTNQQ EASVERQQQP PPETFDFKIK
     FAETKAHAKA IEMELRQMEV AQANRHMSLL TAFMPDSFLR PGGDHDCVLV LLLMPRLICK
     AELIRKQAQE KFELSENCSE RPGLRGAAGE QLSFAAGLVY SLSLLQATLH RYEHALSQCN
     VDVYKKVGSL YPEMSAHERS LDFLIELLHK DQLDETVNVE PLTKAIKYYQ HLYSIHLAEQ
     PEDCTMQLAD HIKFTQSALD CMSVEVGRLR AFLQGGQEAT DIALLLRDLE TSCSDIRQFW
     DKNGFGVSDT LLDCRKHLTW VVAVLQEVAA AAAQLIAPLA ENEGLPVAAL EELAFKASEQ
     IYGTPSSSPY ECLRQSCKIL ISTMNKLATA MQEGEYDAER PPSKPPPVEL RAAALRAEIT
     DAEGLGLKLE DRETVIKELK KSLKIKGEEL SEANVRLSLL EKKLDSAAKD ADERIEKVQT
     RLEETQALLR KKEKEFEETM DALQADIDQL EAEKAELKQR LNSQSKRTIE GLRGPPPSGI
     ATLVSGIAGG EYSRIGGIPG QAPGSVPGPG LVKDSPLLLQ QISAMRLHIS QLQHENTILK
     GAQMKASLAS LPPLHVAKLS HEGPSSELAA GALYRKTSQL LETLNQLSTH THVVDITRTS
     PAAKSPSAQL MEQVAQLKSL SDTIEKLKDE VLKETVSQRP GATVPTDFAT FPSSAFLRAK
     EEQQDDTVYM GKVTFSCAAG LGQRHRLVLT QEQLHQLHSR LIS
//