ID   A0A2K5C526_AOTNA        Unreviewed;      2078 AA.
AC   A0A2K5C526;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Dedicator of cytokinesis 7 {ECO:0000313|Ensembl:ENSANAP00000003816.1};
GN   Name=DOCK7 {ECO:0000313|Ensembl:ENSANAP00000003816.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000003816.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000003816.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   Ensembl; ENSANAT00000021513.1; ENSANAP00000003816.1; ENSANAG00000016461.1.
DR   GeneTree; ENSGT00940000155661; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd08696; C2_Dock-C; 1.
DR   CDD; cd11703; DHR2_DOCK7; 1.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR037808; C2_Dock-C.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR021816; DOCK_C/D_N.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR027357; DOCKER_dom.
DR   InterPro; IPR046769; DOCKER_Lobe_A.
DR   InterPro; IPR046770; DOCKER_Lobe_B.
DR   InterPro; IPR046773; DOCKER_Lobe_C.
DR   PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR   PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR   Pfam; PF06920; DHR-2_Lobe_A; 1.
DR   Pfam; PF20422; DHR-2_Lobe_B; 1.
DR   Pfam; PF20421; DHR-2_Lobe_C; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   Pfam; PF11878; DOCK_C-D_N; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS51651; DOCKER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          532..698
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   DOMAIN          1618..2052
FT                   /note="DOCKER"
FT                   /evidence="ECO:0000259|PROSITE:PS51651"
FT   REGION          110..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          862..886
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..129
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        862..885
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2078 AA;  236256 MW;  675F2DC758E138E3 CRC64;
     FLHYRTVAAE VRKQISGQYS GSPQLLKNLN IVGNISHHTT VMFCKCQLDL LDDDAVEFCC
     ILFDFLESAE KRFLAFCSEM DPHVRDCIRS YTEDWAIVIR KYHKLGTGFN PNTLDKQKER
     QKGLPKQVFE SDEAPDGNNY QDDQDDLKRR SVSIDDTPRG SWACSIFDLK NSLPDALLPN
     LLDRTPNEEI DRQNDDQRKS NRHKELFALH PSPDEEEPIE RLSVPDVPKE HFGQRLLVKC
     LSLKFEIEIE PIFASLALYD VKEKKKISEN FYFDLNSEQM KGLLRPHVPP AAITTLARSA
     IFSITYPSQD VFLVIKLEKV LQQGDIGECA EPYMIFKEAD ATKNKEKLEK LKSQADQFCQ
     RLGKYRMPFA WTAIHLMNIV SSAGSLERDS TEVEISTGER KGSWSERRNS SIVGRRSLER
     TTSGDDACNL TSFRPATLTV TNFFKQEGDR LSDEDLYKFL ADMRRPSSVL RRLRPITAQL
     KIDISPAPEN PHYCLTPELL QVKLYPDSRV RPTREILEFP ARDVYVPNTT YRNLLYIYPQ
     SLNFANRQGS ARNITVKVQF MYGEDPSNAM PVIFGKSSCS EFSKEAYTAV VYHNRSPDFH
     EEIKVKLPAT LTDHHHLLFT FYHVSCQQKQ NTPLETPVGY TWIPMLQNGR LKTGQFCLPV
     SLEKPPQAYS VLSPEVPLPG MKWVDNHKGV FNVEVVAVSS IHTQDPYLDK FFALVNALDE
     HMFPVRIGDM RIMENNLENE LKSSISALNT SQLEPVVRFL HLLLDKLILL VVRPPVIAGQ
     IVNLGQASFE AMASIINRLH KNLEGNHDQH GRNSLLASYI YYVFRLPNTY PNSSSPGPGG
     LGGSVHYATM ARSAVRPASL NLNRSRSLSN SNPDISGTPT SPDDEVRSII GSKAMDRSCN
     RMSSHTETSS FLQTLTGRLP TKKLFHEELA LQWVVCSGSV RESALQQAWF FFELMVKSMV
     HHLYFNDKLD APRKSRFPER FMDDIAALVS TIASDIVSRF QKDTEMVERL NTSLAFFLND
     LLSVMDRGFV FSLIKSCYKQ VSSKLYSLPN PSVLVSLRLD FLRIICSHEH YVTLNLPCSL
     LTPPASPSPS VSSATSQSSG FSTNVQDQKI ANMFELSVPF RQQHYLAGLV LTELAVILDP
     DAEGLFGLHK KVINMVHNLL SSHDSDPRYS DPQIKARVAM LYLPLIGIIM ETVPQLYDFT
     ETHNQRGRPI CIAPDDYESE SGSMISQTVA MAIAGTSVPQ LTRPGSFLLT STSGRQHTTF
     SAESSRSLLI CLLWVLKNAD ETVLQKWFTD LSVLQLNRLL DLLYLCVSCF EYKGKKVFER
     MNSLTFKKSK DMRAKLEEAI LGSIGARQEM VRRSRGQLGT YTIASPSERS PSGSAFGSQE
     NLRWRKDMTH WRQNTEKLDK SRAEIEHEAL IDGNLATEAN LIILDTLEIV VQTVSVTESK
     ESILGGVLKV LLHSMACNQS AVYLQHCFAT QRALVSKFPE LLFEEETEQC ADLCLRLLRH
     CSSSISTIRS HASASLYLLM RQNFEIGNNF ARVKMQVTMS LSSLVGTSQN FNEEFLRRSL
     KTILTYAEED LELRETTFPD QVQDLVFNLH MILSDTVKMK EHQEDPEMLI DLMYRIAKGY
     QTSPDLRLTW LQNMAGKHSE RSNHAEAAQC LVHSAALVAE YLSMLEDRKY LPVGCVTFQN
     ISSNVLEESA VSDDVVSPDE EGICSGKYFT ESGLVGLLEQ AAASFSMAGM YEAVNEVYKV
     LIPVHEANRD AKKLSTIHGK LQEAFSKIVH QDGKRMFGTY FRVGFYGTKF GDLDEQEFVY
     KEPAITKLAE ISHRLEGFYG ERFGEDVVEV IKDSNPVDKC KLDPNKAYIQ ITYVEPYFDT
     YEMKDRITYF DKNYNLRRFM YCTPFTLDGR AHGELHEQFK RKTILTTSHA FPYIKTRVNV
     THKEEIILTP IEVAIEDMQK KTQELAFATH QDPADPKMLQ MVLQGSVGTT VNQGPLEVAQ
     VFLSEIPSDP KLFRHHNKLR LCFKDFTKRC EDALRKNKSL IGPDQKEYQR ELERNYHRLK
     EALQPLINRK IPQLYKAVLP VTCHRDSFSR MSLRKMDL
//