ID A0A2K5C7R7_AOTNA Unreviewed; 2510 AA.
AC A0A2K5C7R7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Collagen type VI alpha 3 chain {ECO:0000313|Ensembl:ENSANAP00000004733.1};
GN Name=COL6A3 {ECO:0000313|Ensembl:ENSANAP00000004733.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000004733.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000004733.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSANAT00000022490.1; ENSANAP00000004733.1; ENSANAG00000020236.1.
DR GeneTree; ENSGT00940000156462; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd22629; Kunitz_collagen_alpha3_VI; 1.
DR CDD; cd01481; vWA_collagen_alpha3-VI-like; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 9.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50234; VWFA; 9.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 13..188
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 205..379
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 399..575
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 603..774
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 806..979
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1009..1182
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1208..1394
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1742..1921
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1959..2155
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2329..2424
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2445..2495
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 1412..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2200..2223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2285..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1502..1522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2510 AA; 272409 MW; 58F17371A5EC6980 CRC64;
MLPPTVIEVN KRDIVFLVDG TSALGLANFN AIRDFIAKVI QRLEIGQDLI QVAVAQYADT
VRPEFYFNTY PAKKDIITAV RKMKPLDGSA LYTGSALDFV RNNLFTSSAG YRDADGIPKV
LVLITGGKSL DEISQPAQEL KRSSIMAFAI GNKGADQAEL EEIAFDSSLV FIPAEFRAAP
LQGMLPGLLA PLRTLSGTPE ESKRDILFLF DGSANLVGQG QFPLVRDFLY KIIDELNVQP
DGTRIAVAQY SDDVKVESRF DEHQSKPDIL NLVKRMKIKT GKALNLGYAL DYAQRYIFVK
SAGSRIEDGV PQFLVLLVAG RSSDRVDGPA SNMKQSGIVP FIFQAKNADP AELEQIVLSP
AFILAAESLP KIGDLQPQIV NLLKTVHNGA PARVSGEKDV VFLLDGSEGV RSGFPLLKEF
VQRVVESLDV GQDRVRVAVV QYSDRTRPEF YLNSYMNQQD VVNAIRQLTL LGGPTPNTGA
ALEFVLRNIL VSSAGSRITE GVPQLLIVVT ADRSGDDVRN PSVVLKRGGA VPIGIGIGNA
DITEMQTISF IPDFAVAIPT FRQLGTIQQV ISERVTQLTR EELSRLQPVL QPLPSPGVGG
KRDVVFLIDG SQSAGPEFQH IRTLIERLVE FLDVGFDTTR VAVIQFSDDP KVEFLLNAHS
SKDEVQNAVR RLRPKGGRQV NLGSALEYVS RNIFKRPLGS RIEEGVPQFL VLVSSGKSDD
EVDEPAVELK QFGVAPLTIA RNADKEELVK ISLSPEYVFS VSTFQELPSL EQKLLTPITS
LTSDHIQQLL ASTQYPPPAV ESDAADIVFL IDSSEGVRSE GFAHIRDFVI RIVRRLNIGP
SKVRVGVVQF SNDVFPEFYL KTYRSQVPVL EAIRRLRLRG GSPLNTGKAL EFVARNFFVK
SAGSRIEDGV PQHLVLVLGG KSQDDVSRFA QVIRSSGIVS LGVGDRNIDR TELQTITNDP
RLVFTVREFR DLPNIEERIM NSFGPSAATP APPGVDIPPP SLPEKKKADI VFLLDGSINF
RRDSFQEVLR FVSEVVDTVY EDGDSIQVGL VQYNSDPTDE FFLRDFSTKR QIIDAINKVV
YKGGRHANTK VGLEHLRVNH FVPEAGSRLE QRVPQIAFVV TGGKSVEDAQ HVSLALTQRG
VKVFAVGVRN IDSEEVGKIA SNSATAFRVG NVQELSELSE QVLETLHDAM HETLCPGVTD
VARACNLDVI LGFDGSRDQN VFVAQKGFES KVDAILNRIS QMHRVSCSGG RSPTVRVSVV
ATTPSGPVEA FDFDEYQPEM LEKFRNMRSQ HPYVLTADTL KVYQNKFRQS SPDSVKVVIH
FTDGADGDRA DLHRASEDLR QEGVRALILV GLERVANLEN LMHLEFGRGF MYDRPLRLNL
LDLDYELAEQ LDNIAEKACC GVPCKCSGQR GDRGPIGSIG PKGFPGEDGY RGYPGDEGGP
GERGPPGVNG TQGFQGCPGQ RGIKGSRGFP GEKGEVGEIG LDGLDGEEGD KGLPGSSGEK
GNPGRRGDKG PRGEKGERGD AGIRGDPGNP GQDSQQRGPK GETGDIGPVG VPGIDGVPGG
PGETGKNVSA FRPLRGGNKG GPGQPGFEGE QGTRGAQGPP GPAGPPGLIG EQGISGPRVS
LGHLPSRLSG EPGEPGPKGG IGNRGPRGET GDDGRDRVGS EGRRGKKGNP GQPGLNGAPG
PKGIRGRRGN SGPPGIVGQK GDPGYPGPTE RKPPFCSTCG LSLTFHLPLS TGPLECPVFP
TELAFALDTS EGVTQDTFSR MRDVVLSIVN DLTVAESNCP RGARVAVVTY NNEVTTEIRF
ADSKKKSVLL DKIKNLQVAL TSKQQSLETA MSFVARNTFK RVRNGFLMRK VAVFFSNRPT
RASPQLGEAV LKLSDAGITP LFLTSQEDRQ LINALQINNT AVGHALVLPA RRDLTDFLKN
VLTCHVCLDI CNIDPSCGFG SWRPSFRDRR AAGSDVDIDM AFILDSAETT SLFQFSEMKK
YIAYLIRQLD ISPDPKASQH FARVAVVQHA PYESVGDASV PPVKVEFSLT DYGSKEKLLD
FLSRGMTQLQ GTRALGSAIE YTIENVFKSA PNPRDLKIVV LMLTGEVQEQ QLEEAQKVIL
QAKCQGYFFV VLGIGRKVNV KEVYTFASEP NDVFFKLVDK STELSEEPLM RFGRLFPSFV
SSENAFYLSP DIRKQCDWFQ GDQPKKNLVK YGHKQVNIPN NVTSSPTFNP PVTTTKPVTT
TKPVTTTTKP VTIVNQTSVK PADAKPAPAK PAPAKPVAAK PVATKAATVR PPVVVKPAVA
AKPAAAKPAA ARPPAAVAKP VATKPEASRP QAAKPAATKP ATTKPVVKAS QEVQVFDITE
NSVKLHWERP DPYSPYFYDL TVTSAHDQSL VLKQNLSITD RIIGGLLPGQ TYHVAVVCYL
KSQVRATYHG SFSTRSSDCQ PQHGEQSNTH VLTNVLCHLV IKDICKLPKD EGTCRDFILK
WYYDPNTKSC ARFWYGGCGG NENKFGSQKE CEKVCAPVLA KPGVINVIGT
//
