ID A0A2K5C839_AOTNA Unreviewed; 404 AA.
AC A0A2K5C839;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=B-box and SPRY domain containing {ECO:0000313|Ensembl:ENSANAP00000004839.1};
GN Name=BSPRY {ECO:0000313|Ensembl:ENSANAP00000004839.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000004839.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000004839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Can form homodimers and homotrimers. In addition to lower-
CC order dimerization, also exhibits a higher-order multimerization and
CC both low- and high-order multimerizations are essential for its
CC restriction activity. Interacts with BTBD1 and BTBD2. Interacts with
CC PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain)
CC with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3.
CC Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with
CC ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A,
CC MAP1LC3C and BECN1. {ECO:0000256|ARBA:ARBA00011109}.
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DR RefSeq; XP_012317297.1; XM_012461874.1.
DR AlphaFoldDB; A0A2K5C839; -.
DR STRING; 37293.ENSANAP00000004839; -.
DR Ensembl; ENSANAT00000022597.1; ENSANAP00000004839.1; ENSANAG00000020528.1.
DR GeneID; 105723699; -.
DR CTD; 54836; -.
DR GeneTree; ENSGT00940000161096; -.
DR OMA; HESELDW; -.
DR OrthoDB; 5296458at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd19834; Bbox2_BSPRY; 1.
DR CDD; cd12904; SPRY_BSPRY; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24103:SF568; B BOX AND SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 214..404
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 44797 MW; D49FDDB971C56B0F CRC64;
MSAEGTEPGS GSGPGPGPEP GPLCPEHGQA LSWFCGSERR PVCAACTGLD GRCRGHRIRR
AEERAEELRN KIVDQCERLQ LQSAGISKYM ADVLPGKNQR AVSMASAARE LVIQRLSLVR
SLCESEEQRL LEQVHGEEER AHQSILTQRV HWAEALQKLD TIRTGLVGML THLDDLQLIQ
KEQEIFERTE EAEGILDPQE SEMLNFNEKC TRSPLLTQLW ATAVLGSLSG TEDIRIDERT
VSPFLQLSDD RKTLTFSTKK SKPCADGPER FDHWPNALAA TSFQDGLHAW IVNVQNSCAY
KVGVASGHLP RKGSGSDCRL GHNAFSWVFS RYDQEFRFSH NGQHEPLGLL RGPAQLGVLL
DLQARELLFY EPASGTVLYT YHGAFPGPVF PVFAVADQTI SVIR
//
