ID A0A2K5C9R2_AOTNA Unreviewed; 445 AA.
AC A0A2K5C9R2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DDB1- and CUL4-associated factor 13 {ECO:0000256|ARBA:ARBA00021762};
DE AltName: Full=WD repeat and SOF domain-containing protein 1 {ECO:0000256|ARBA:ARBA00032239};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000005441.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000005441.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC {ECO:0000256|ARBA:ARBA00005649}.
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DR AlphaFoldDB; A0A2K5C9R2; -.
DR STRING; 37293.ENSANAP00000005441; -.
DR Ensembl; ENSANAT00000023203.1; ENSANAP00000005441.1; ENSANAG00000020798.1.
DR GeneTree; ENSGT00390000005711; -.
DR OMA; EDHNAYI; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0046697; P:decidualization; IEA:Ensembl.
DR GO; GO:0044725; P:epigenetic programming in the zygotic pronuclei; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0007056; P:spindle assembly involved in female meiosis; IEA:Ensembl.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR007287; Sof1.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22851:SF0; DDB1- AND CUL4-ASSOCIATED FACTOR 13; 1.
DR PANTHER; PTHR22851; U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF04158; Sof1; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 62..104
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 199..307
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REPEAT 278..319
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 321..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 354..440
FT /note="Sof1-like protein"
FT /evidence="ECO:0000259|Pfam:PF04158"
SQ SEQUENCE 445 AA; 51409 MW; 37FFB411D281D8CB CRC64;
MKVKMLSRNP DNYVRETKFD LQRVPRNYDP ALHPFEVPRE YVRALNATKL ERVFAKPFLA
SLDGHRDGVN CLAKHPKNLA TVLSGACDGE VRIWNLTQRK CIRTIQAHEG FVRGICTRFC
GTSFFTVGDD KTVKQWKMDG PGYGEEEEPL HTILGKTVYT GIDHHWKEAV FATCGQQVDI
WDEQRTNPIC SMTWGFDSIS SVKFNPIETF LLGSCASDRN IVLYDMRQAT PLKKVILDMR
TNTICWNPME AFIFTAANED YNLYTFDMRA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
SFDKSIRIFP VDKSRSREVY HTKRMQHVIC VKWTSDSKYI MCGSDEMNIR LWKANASEKL
GVLTSREKAA KDYNQKLKEK FQHHPHIKRI ARHRHLPKSI YSQIQEQRIM KEARRRKEVN
RIKHSKPGSV PVVSEKKKHI VAVVK
//
