ID A0A2K5CBA8_AOTNA Unreviewed; 2445 AA.
AC A0A2K5CBA8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Notch receptor 2 {ECO:0000313|Ensembl:ENSANAP00000005983.1};
GN Name=NOTCH2 {ECO:0000313|Ensembl:ENSANAP00000005983.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000005983.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000005983.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSANAT00000023747.1; ENSANAP00000005983.1; ENSANAG00000020885.1.
DR GeneTree; ENSGT00940000155030; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 27.
DR CDD; cd21703; JMTM_Notch2; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 35.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022336; Notch_2.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF229; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00008; EGF; 21.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01985; NOTCH2.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 35.
DR SMART; SM00179; EGF_CA; 34.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 33.
DR PROSITE; PS01186; EGF_2; 28.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1652..1674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..37
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 38..76
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 79..117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 118..154
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 156..193
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 195..232
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 234..270
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 272..310
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 312..348
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 349..387
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 389..428
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 430..466
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 468..504
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 506..542
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 544..579
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 581..617
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 619..654
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 656..692
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 694..729
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 731..767
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 769..805
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 807..845
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 847..883
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 885..921
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 923..959
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 961..997
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 999..1035
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1037..1073
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1086..1121
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1123..1159
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1161..1197
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1199..1236
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1238..1276
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1278..1317
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1349..1386
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1399..1439
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1440..1476
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1477..1518
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1850..1882
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1917..1949
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1950..1982
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1983..2015
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1727..1762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2065..2142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2354..2445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2097..2112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2113..2142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2358..2377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2393..2421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 410
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 430
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 433
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 447
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 471
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 485
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 486
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 27..36
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 47..64
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 66..75
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 107..116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 144..153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 183..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 222..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 260..269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 300..309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 338..347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 358..375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 377..386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 393..407
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 401..416
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 418..427
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 434..445
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 439..454
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 456..465
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 472..483
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 477..492
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 494..503
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 532..541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 548..558
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 569..578
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 607..616
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 623..633
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 644..653
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 682..691
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 698..708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 719..728
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 757..766
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 795..804
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 816..833
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 835..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 873..882
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 911..920
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 949..958
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 987..996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1025..1034
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1063..1072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1111..1120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1149..1158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1187..1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1226..1235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1247..1264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1266..1275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1307..1316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1357..1374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1376..1385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2445 AA; 262258 MW; C082B5238FB6B910 CRC64;
PCRDGYEPCV NEGICVTYHN GTGYCKCPEG FLGEYCQHRD PCEKNRCQNG GTCVAQAMLG
KATCRCASGF TGEDCQYSTS HPCFVSRPCL NGGTCHMLSR DTYECTCQVG FTGKLCQWTD
ACLSHPCANG STCTTVANQF SCKCLTGFTG QKCETDVNEC DIPGHCQHGG TCLNLPGSYQ
CQCPQGFTGQ HCDSPYVPCA PSPCVNGGTC RQTGDFTFEC NCLPGFEGNT CEKNIDDCPN
HKCQNGGVCV DGVNTYNCRC PPQWTGQFCT EDVDECLLQP NACQNGGTCA NRNGGFGCVC
VNGWSGDDCS ENIDDCAFAS CTPGSTCIDR VASFSCMCPE GKAGLLCHLD DACISNPCHK
GALCDTNPLN GQYICTCPQG YKGADCTEDV DECAMANSNP CEHAGKCVNT EGGFHCECLK
GYAGPRCEMD INECHSDPCQ NDATCLDKIG GFTCLCMPGF KGVHCELEIN ECQSNPCVNN
GQCVDKVNRF QCLCPPGFTG PVCQIDIDDC SSTPCLNGAK CIDHPNGYEC QCATGFTGVL
CEENIDNCDP DPCHHGQCQD GIDSYTCICS PGYMGTICSD QIDECYSSPC LNDGRCIDLV
NGYQCNCQPG TSGVNCEINF DDCTSNPCVH GICMDGINHY SCVCSPGFTG QRCNIDIDEC
ASNPCRKGAT CVNGVNGFRC ICPEGPHHPS CYSQVNECLS NPCIHGNCTG GLSGYKCLCD
AGWVGINCEV DKNECLSNPC QNGGTCDDLV NGYRCTCPKG FKGYNCQVNI DECASNPCLN
QGTCFDDISG YTCHCVLPYT GKNCQAVLAP CSPNPCENAA VCKESPNFDS YTCLCAPGWQ
GQQCTIDIDE CISKPCMNHG LCHNTQGSYV CECPPGFSGM DCEEDIDDCL ANPCQNGGSC
VDGVNTFSCL CLPGFTEDKC QTDVNECLNE PCKNGGTCSD YVNSYTCKCQ AGFDGVHCEN
NIDECTESSC FNGGTCVDGV NSFSCLCPVG FTGPFCLHEI NECSSHPCLN EGTCVDGLGT
YHCTCSLGYT GKNCQTLVNL CSQSPCKNKG TCIQEKAESR CLCPSGWAGA YCDVPNVSCD
IAASSRGVPV EHLCQHSGVC INAGNTHYCQ CPLGYTGSYC EEQLNECASN PCHHGATCSD
FIGGYRCECV PGFQGVNCEY EVDECQNQPC QNGGTCIDLV NHFKCSCPPG SRGLLCEENI
DDCVGGPHCL NGGQCVDRIG GYSCRCLPGF AGERCEGDIN ECLSNPCSSE GSLDCIQLTN
DYLCVCRSAF TGRHCETFID VCPQMPCLNG GTCAVASNMP DGFICHCPPG FSGARCQSSC
GQVKCKKGEQ CVHTASGPRC FCPNPRDCES GCASSPCQHG GSCHPQRQPP FYSCQCTPPF
WGSLCELYTA PPSTPPATCL SQYCADKARD GVCDEACNSH ACQWDGGDCS LTMENPWANC
SSPLPCWDYI NNQCDELCNT AECLFDNFEC QGNSKTCKYD KYCADHFKDN HCDQGCNSEE
CGWDGLDCAA DQPENLAEGT LVIVVLLPPE QLLQDVRSFL RALGTLLHTN LRIKRDSKGE
PMVYPYYGEK SAAMKKQRMT RRSLPGEQEQ EVAGSKVFLE IDNRQCVQDS DHCFKNTDAA
AALLASHAIR GTLSYPLVSV ISESPTPERT QLLYLLAVAV VIILFIILLG VIMAKRKRKH
GSLWLPEGFT LRRDASNHKR REPVGQDAVG LKNLSVQVSE ANLIGSGTSE HWVDDEGPQP
KKVKAEDEAL LSEEDDPIDR RPWTQQHLEA ADIRRTPSLA LTPPQAEQEV DVLDVNVRGP
DGCTPLMLAS LRGGSSDLSD EDEDAEDSSA NIITDLVYQG ASLQAQTDRT GEMALHLAAR
YSRADAAKRL LDAGADANAQ DNMGRCPLHA AVAADAQGVF QILIRNRVTD LDARMNDGTT
PLILAARLAV EGMVAELINC QADVNAVDDH GKSALHWAAA VNNVEATLLL LKNGANRDMQ
DNKEETPLFL AAREGSYEAA KILLDHFANR DITDHMDRLP RDVARDRMHH DIVRLLDEYN
VTPSPPGTVL TSALSPVICG PNRSFLSLKH TPMGKKSRRP SAKSTMPTSL PNLAKEAKDA
KGSRRKKSVS EKVQLSESSV TLSPVDSLES PHTYVSDTTS SPMITSPGIL QASPNPMLAT
AAPPAPVHAQ HALSFSNLHE MQPLAHGAST VLPSVSQLLS HHHIVPPGSG SAGSLSRLHP
VPVPADWMNR MEVNETQYNE MFGMVLAPAE GTHPGIAPQS RPPEGKHITT PREPLPPIVT
FQLIPKGSIA QPTGAPQPQS TCPPAVAGPL PTMYQIPEMA RLPSMAFPTA MMPQQDGQVA
QTILPAYHPF PASVGKYPTP PSQHSYASSN AAERTPSHSG HLQGEHPYLT PSPESPDQWS
SSSPHSASDW SDVTTSPTPG GAGGGQRGPG THMSEPPHNN MQVYA
//
