ID A0A2K5CCE2_AOTNA Unreviewed; 646 AA.
AC A0A2K5CCE2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Zinc finger protein 74 {ECO:0000313|Ensembl:ENSANAP00000006304.1};
GN Name=ZNF74 {ECO:0000313|Ensembl:ENSANAP00000006304.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000006304.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000006304.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_012294682.1; XM_012439259.1.
DR AlphaFoldDB; A0A2K5CCE2; -.
DR STRING; 37293.ENSANAP00000006304; -.
DR Ensembl; ENSANAT00000024072.1; ENSANAP00000006304.1; ENSANAG00000021232.1.
DR GeneID; 105708094; -.
DR CTD; 7625; -.
DR GeneTree; ENSGT00940000162000; -.
DR OMA; RPEWQLK; -.
DR OrthoDB; 4718324at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF140; ZINC FINGER PROTEIN 726; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 43..116
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 250..277
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 278..305
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 306..333
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 334..361
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 362..389
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 390..417
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 418..445
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 446..473
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 474..501
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 502..529
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 530..557
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 558..585
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 72322 MW; 7D4D1EE88A562E9D CRC64;
METPAPESKK TVLSSQDPAF SLKENPEDIS GWGLPEARSK ESVSFKDVAV DFTQEEWGQL
DSPQRALYWD VMLENYQNLL ALGAGPPLHK PDVISHLERG EEPWCVQRDV PGGPCPEWEM
KEVPSQQQGM CKEEPAQEPI LEWPLGGAQA WGRQACALQR SQAAPWAPAP ASVWDVPIEE
FPLRCALFAQ QRVPEGEHSL DTHKDVQATE CGTKAPARLC AGENASTPSE PEKFPAARRQ
RGAGAGEGEF LCGECGKAFR QSSSLTLHQR WHSREKAYKC EECGKAFTWS TNLLEHRRIH
TGEKPFFCSE CGKAFSCHSS LNVHQRIHTG ERPYKCSACE KAFSCSSLLS MHLRVHTGEK
PYRCGECGKA FNQRTHLTRH HRIHTGEKPY QCGSCGKAFT CHSSLTVHEK IHSGDKPFKC
SDCEKAFNSR SRLTLHQRTH TGEKPFKCAD CGKGFSCHAY LLVHRRIHSG EKPFKCNECG
KAFSSHAYLI VHRRIHTGEK PFDCSQCWKA FSCHSSLIVH QRIHTGEKPY KCGECGRAFS
QNHCLIKHQK IHSGEKSFKC EECGEMFNWS SHLTEHQRLH SEGKPLAIQF NKHLLSTYYV
PGSLLGAGNA GLRDVDPINA LDVAKLLCVV PPRVGRNFPL GSKPRN
//
