ID A0A2K5CEI2_AOTNA Unreviewed; 568 AA.
AC A0A2K5CEI2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Microcephalin {ECO:0000256|ARBA:ARBA00017027};
GN Name=MCPH1 {ECO:0000313|Ensembl:ENSANAP00000007061.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000007061.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000007061.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Implicated in chromosome condensation and DNA damage induced
CC cellular responses. May play a role in neurogenesis and regulation of
CC the size of the cerebral cortex. {ECO:0000256|ARBA:ARBA00025455}.
CC -!- SUBUNIT: Interacts with CDC27 and maybe other components of the APC/C
CC complex. Interacts with histone variant H2AX under DNA damage
CC conditions. {ECO:0000256|ARBA:ARBA00026061}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR AlphaFoldDB; A0A2K5CEI2; -.
DR Ensembl; ENSANAT00000024834.1; ENSANAP00000007061.1; ENSANAG00000021601.1.
DR GeneTree; ENSGT00390000018842; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0021987; P:cerebral cortex development; IEA:InterPro.
DR CDD; cd17716; BRCT_microcephalin_rpt1; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR022047; Microcephalin-like.
DR InterPro; IPR029504; Microcephalin_mammal.
DR PANTHER; PTHR14625; MICROCEPHALIN; 1.
DR PANTHER; PTHR14625:SF3; MICROCEPHALIN; 1.
DR Pfam; PF12258; Microcephalin; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 1..93
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 285..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 62844 MW; 637FA96203C13DEA CRC64;
MAAPILKDVV AYVEVWSSNG TENYSKTFTT QLMDMGAKVS KTFNKQVTHV IFKDGYQSTW
DKAQKRGVKL VSVLWVEKCR TAGAHVDESL FPAANMKEHL PSLIKKKRKC MQPKDFNFKT
PENDKRFQKK IEKMAEELQR QKTSLASQMI QQSHDNPSNS LCEAPLNISH DALCSDESFA
GGLHSSFDVL CGNSGCGNQE RKLGRSVNDI KSDTCISSLV LMTNNIHSSP SFTYPDKSSP
QKFLNNVSKE EINLERNIVG KIVTPDQKQA AGVSQETFEE YRLSPMLSTT KGHPSIHSRP
RSSSVKRKRI SDGSCSPAKE KCKRKQSIRR SIMPRLQLCK SEGSLQRVAG PKLEALSCEE
SSYDDYFSPD NLKERNSENL PPESQLPSSP AQFSCRSLSK KERTNILEMS DFSCVGKITR
TVDITSFIAK TISSPRKPAN GEGHATLSCV TSEESFAPEE TLRCGRQAGP QQKDDACPGG
DGFSYPVEDP ALPKGQDGDL TPLEGSLEEL KEAVRLKSTE NEGTTSKISN SSEGEAQSEH
EPHFVVDCNV ERSTEEKENL PTGYPGSM
//
