ID A0A2K5CF26_AOTNA Unreviewed; 164 AA.
AC A0A2K5CF26;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=T-cell surface glycoprotein CD3 zeta chain {ECO:0000256|ARBA:ARBA00020448};
DE AltName: Full=T-cell receptor T3 zeta chain {ECO:0000256|ARBA:ARBA00030941};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000007224.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000007224.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the CD3Z/FCER1G family.
CC {ECO:0000256|ARBA:ARBA00007280}.
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DR AlphaFoldDB; A0A2K5CF26; -.
DR STRING; 37293.ENSANAP00000007224; -.
DR Ensembl; ENSANAT00000025000.1; ENSANAP00000007224.1; ENSANAG00000021685.1.
DR GeneTree; ENSGT00390000018208; -.
DR OMA; EMGGKQP; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0042105; C:alpha-beta T cell receptor complex; IEA:Ensembl.
DR GO; GO:0033001; C:Fc-gamma receptor III complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IEA:Ensembl.
DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR InterPro; IPR024128; T-cell_CD3_zeta.
DR PANTHER; PTHR10035; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR PANTHER; PTHR10035:SF2; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR Pfam; PF02189; ITAM; 2.
DR Pfam; PF11628; TCR_zetazeta; 1.
DR SMART; SM00077; ITAM; 3.
DR PROSITE; PS51055; ITAM_1; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..164
FT /note="T-cell surface glycoprotein CD3 zeta chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014391402"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 83..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 164 AA; 18609 MW; 1A05F58428B1B1AA CRC64;
MQWKALVTAA ILQAQLPSTE AQSFGLLDPK LCYLLDGILF IYGVIVTALF LRVKFSRSAD
APVYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKQ QRRKNPQEGL YNALQKDKMA
EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR
//
