ID   A0A2K5CFR5_AOTNA        Unreviewed;      1575 AA.
AC   A0A2K5CFR5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=DEP domain containing 5, GATOR1 subcomplex subunit {ECO:0000313|Ensembl:ENSANAP00000007481.1};
GN   Name=DEPDC5 {ECO:0000313|Ensembl:ENSANAP00000007481.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000007481.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000007481.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012326740.1; XM_012471317.1.
DR   Ensembl; ENSANAT00000025259.1; ENSANAP00000007481.1; ENSANAG00000021641.1.
DR   GeneID; 105730252; -.
DR   CTD; 9681; -.
DR   GeneTree; ENSGT00390000016559; -.
DR   OrthoDB; 946033at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04449; DEP_DEPDC5-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR048255; IML1_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR   PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          1159..1234
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          399..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          669..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          986..1007
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1100..1137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        987..1001
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1575 AA;  177887 MW;  55F754ECB1FE227D CRC64;
     MRTTKVYKLV IHKKGFGGSD DELVVNPKVF PHIKLGDIVE IAHPNDEYSP LLLQVKSLKE
     DLQKETISVD QTVTQVFRLR PYQDVYVNVV DPKVSTCAYI TQKVEFAGIR AQAGELWVKN
     EKVMCGYISE DTRVVFRSTS AMVYIFIQMS CEMWDFDIYG DLYFEKAVNG FLADLFTKWK
     EKNCSHEVTV VLFSRTFYDA KSVDEFPEIN RASIRQDHKG RFYEDFYKVV VQNERREEWT
     SLLVTIKKLF IQYPVLVRLE QAEGFPQGDN STSAQGNYLE AINLSFNVFD KHYINRNFDR
     TGQMSVVITP GVGVFEVDRL LMILTKQRMI DNGIGVDLVC MGEQPLHAVP LFKLHNRSAP
     RDSRLGDDYN IPHWINHSFY TSKSQLFCNS FTPRIKLAGK KPASEKAKNG RDTSLGSPKE
     SENALPIQVD YDAYDAQVFR LPGPSRAQCL ATCRSVRERE SHSRKSASSC DVSSSPSLPS
     RTLPTEEVRS QASDDSSLGK SANILMIPHP HLHQYEVSSS LGYTSTRDVL ENMMEPPQRD
     SSAPGRFHVG SAESMLHVRP GGYTPQRALI NPFAPSRMPM KLTSNRRRWM HTFPVGPSGE
     AIQIHHQTRQ NMAELQGSGQ RDPTHSSAEL LELAYHEAAG RHSNSCQPGD GMSFLNFSGT
     EELSVSLLSN SGAGMNPRTQ NKDPLEDSVS TSPDPILTLS APPVVPGFCC TVGVDWKSLT
     TPACLPLTTD YFPDRQGLQN DYTEGCYDLL PEADIDRRDE EGVQMTAQQV FEEFICQRLM
     QGYQIIVQPK AQKPSPAVPP PLSSSPLYSR GLVSRNRPEE EDQYWLSMGR TFHKVTLKDK
     MITVTRYLPK YPYESAQIHY TYSLCPSHSD SEFVSCWVEF SHERLEEYKW NYLDQYICSA
     GSEDFSLIES LKFWRTRFLL LPACVTATKR ITEGEAHCDI YGDRPRADED EWQLLDGFIR
     FVEGLNRIRR RHRSDRMMRK GTTMKGLQMT GPISTHSLES TAPPVGKKGT SALSALLEME
     ASQKCLGEQQ AAVHGGKSSA QPAESSSVAM TPTYMDSPRK DGAFFMEFVR SPRTASSAFY
     PQVSVDQTVT PVLDSTSLGI STGQSVDRGN SQTFGNSQNI GEQGYSSTNS SDSSSQQLVA
     SSLTSSSTLT EILEAMKHPS TGVQLLSEQK GLSPYCFISA EVVHWLVNHV EGIQTQAMAI
     DIMQKMLEEQ LITHASGEAW RTFIYGFYFY KIVTDKEPDR VAMQQPATTW HTAGVDDFAS
     FQRKWFEVAF VAEELVHSEI PAFLLPWLPS RPASYASRHS SFSRSFGGRS QAAALLAATV
     PEQRTVTLDV DVNNRTDRLE WCSCYYHGNF SLNAAFEIKL HWMAVTAAVL FEMVQGWHRK
     ATSCGFLLVP VLEGPFALPS YLYGDPLRAQ LFIPLNISCL LKEGSEHLFD SFEPETYWDR
     MHLFQEAIAH RFGFVQDKYS ASAFNFPAEN KPQYIHVTGT VFLQLPYSKR KFSGQQRRRR
     NSTSSTNQNM FCEERVGYNW AYNTMLTKTW RSSATGDEKF ADRLLKDFTD FCINRDNRLV
     TFWTSCLEKM HASAP
//