ID   A0A2K5CG08_AOTNA        Unreviewed;      1421 AA.
AC   A0A2K5CG08;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=DEP domain containing 5, GATOR1 subcomplex subunit {ECO:0000313|Ensembl:ENSANAP00000007564.1};
GN   Name=DEPDC5 {ECO:0000313|Ensembl:ENSANAP00000007564.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000007564.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000007564.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012326739.1; XM_012471316.1.
DR   Ensembl; ENSANAT00000025342.1; ENSANAP00000007564.1; ENSANAG00000021641.1.
DR   GeneID; 105730252; -.
DR   CTD; 9681; -.
DR   GeneTree; ENSGT00390000016559; -.
DR   OMA; SWMNATP; -.
DR   OrthoDB; 946033at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04449; DEP_DEPDC5-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR048255; IML1_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR   PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          1005..1080
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          276..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          546..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          848..875
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          896..930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          942..985
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..292
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..565
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        855..869
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        902..930
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1421 AA;  160567 MW;  518B144876ADCEB4 CRC64;
     MCGYISEDTR VVFRSTSAMV YIFIQMSCEM WDFDIYGDLY FEKAVNGFLA DLFTKWKEKN
     CSHEVTVVLF SRTFYDAKSV DEFPEINRAS IRQDHKGRFY EDFYKVVVQN ERREEWTSLL
     VTIKKLFIQY PVLVRLEQAE GFPQGDNSTS AQGNYLEAIN LSFNVFDKHY INRNFDRTGQ
     MSVVITPGVG VFEVDRLLMI LTKQRMIDNG IGVDLVCMGE QPLHAVPLFK LHNRSAPRDS
     RLGDDYNIPH WINHSFYTSK SQLFCNSFTP RIKLAGKKPA SEKAKNGRDT SLGSPKESEN
     ALPIQVDYDA YDAQVFRLPG PSRAQCLATC RSVRERESHS RKSASSCDVS SSPSLPSRTL
     PTEEVRSQAS DDSSLGKSAN ILMIPHPHLH QYEVSSSLGY TSTRDVLENM MEPPQRDSSA
     PGRFHVGSAE SMLHVRPGGY TPQRALINPF APSRMPMKLT SNRRRWMHTF PVGPSGEAIQ
     IHHQTRQNMA ELQGSGQRDP THSSAELLEL AYHEAAGRHS NSCQPGDGMS FLNFSGTEEL
     SVSLLSNSGA GMNPRTQNKD PLEDSVSTSP DPMPGFCCTV GVDWKSLTTP ACLPLTTDYF
     PDRQGLQNDY TEGCYDLLPE ADIDRRDEEG VQMTAQQVFE EFICQRLMQG YQIIVQPKAQ
     KPSPAVPPPL SSSPLYSRGL VSRNRPEEED QYWLSMGRTF HKVTLKDKMI TVTRYLPKYP
     YESAQIHYTY SLCPSHSDSE FVSCWVEFSH ERLEEYKWNY LDQYICSAGS EDFSLIESLK
     FWRTRFLLLP ACVTATKRIT EGEAHCDIYG DRPRADEDEW QLLDGFIRFV EGLNRIRRRH
     RSDRMMRKGT TMKGLQMTGP ISTHSLESTA PPVGKKGTSA LSALLEMEAS QKCLGEQQAA
     VHGGKSSAQP AESSSVAMTP TYMDSPRKVS VDQTVTPVLD STSLGISTGQ SVDRGNSQTF
     GNSQNIGEQG YSSTNSSDSS SQQLVASSLT SSSTLTEILE AMKHPSTGVQ LLSEQKGLSP
     YCFISAEVVH WLVNHVEGIQ TQAMAIDIMQ KMLEEQLITH ASGEAWRTFI YGFYFYKIVT
     DKEPDRVAMQ QPATTWHTAG VDDFASFQRK WFEVAFVAEE LVHSEIPAFL LPWLPSRPAS
     YASRHSSFSR SFGGRSQAAA LLAATVPEQR TVTLDVDVNN RTDRLEWCSC YYHGNFSLNA
     AFEIKLHWMA VTAAVLFEMV QGWHRKATSC GFLLVPVLEG PFALPSYLYG DPLRAQLFIP
     LNISCLLKEG SEHLFDSFEP ETYWDRMHLF QEAIAHRFGF VQDKYSASAF NFPAENKPQY
     IHVTGTVFLQ LPYSKRKFSG QQRRRRNSTS STNQNMFCEE RVGYNWAYNT MLTKTWRSSA
     TGDEKFADRL LKDFTDFCIN RDNRLVTFWT SCLEKMHASA P
//