ID A0A2K5CGT6_AOTNA Unreviewed; 611 AA.
AC A0A2K5CGT6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Golgi associated, gamma adaptin ear containing, ARF binding protein 2 {ECO:0000313|Ensembl:ENSANAP00000007854.1};
GN Name=GGA2 {ECO:0000313|Ensembl:ENSANAP00000007854.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000007854.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000007854.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR AlphaFoldDB; A0A2K5CGT6; -.
DR Ensembl; ENSANAT00000025633.1; ENSANAP00000007854.1; ENSANAG00000021971.1.
DR GeneTree; ENSGT00940000159613; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14239; GAT_GGA1_GGA2; 1.
DR CDD; cd17010; VHS_GGA2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF2; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA2; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 31..161
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 186..313
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 482..603
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 436..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 67163 MW; 4E180E23BC2BE6A1 CRC64;
SRLASNRPGV VVVAWSDPAA GPLGVIFWNK ATDPSMSEQD WSAIQNFCEQ VNTDPNGPTH
APWLLAHKIQ SPQEKEALYA LTVLEMCMNH CGEKFHGEVA KFRFLNELIK VLSPKYLGSW
ATEKVKGRVI EILFSWTVWF PEDVKIRDAY QMLKKQGIIK QDPKLPVDKI LPPPSPWPKS
SIFDADEEKS KLLTRLLKSN HPEDLQAANR LIKNLVKEEQ EKSEKVSKRV SAVEEVRSHV
KVLQEMLSMY RRPGQAPPDQ EALQVVYERC EKLRPTLFRL ASDTTDDDDA LAEILQANDL
LTQGVLLYKQ VMEGRVTFGN TVTSSMGDIP VSRVFQNPAG CMKTCALIDL EVDSGPAQAG
TVVPSLLHQD LAALGISDAP VTGTVAGQNC CEEKRNPSAS MLPGSGIQNP SADRNLLDLL
SPQPALGPLN YVSQKSIPKE VPPGTKSSPG WSWEAGPLAP SPSSQNTPLA QVFVPLESVK
PSSLPPLIVY DRNGFRILLH FSQTGAPGHP EVQVLLLTMM STAPQPVWDI MFQVAVPKSM
RVKLQPASSS KLPAFSPLMP PAVISQMLLL DNPHKEPIRL RYKLTFNQGG QPFSEVGEVK
DFPDLAVLGA A
//
