UniProt: A0A2K5CHG5

Database: UniProt
Entry: A0A2K5CHG5_AOTNA

LinkDB:  A0A2K5CHG5_AOTNA 
Original site:  A0A2K5CHG5_AOTNA

All links

Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (37)   
   InterPro (17)   
   Pfam (7)   
   PROSITE (8)   
   SMART (5)   
All databases (45)   

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ID   A0A2K5CHG5_AOTNA        Unreviewed;      4777 AA.
AC   A0A2K5CHG5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=HERC2 {ECO:0000313|Ensembl:ENSANAP00000008071.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000008071.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000008071.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   Ensembl; ENSANAT00000025850.1; ENSANAP00000008071.1; ENSANAG00000021521.1.
DR   GeneTree; ENSGT00940000154975; -.
DR   OMA; HTNGVLY; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd08664; APC10-HERC2; 1.
DR   CDD; cd00078; HECTc; 1.
DR   CDD; cd14402; UBA_HERC2; 1.
DR   CDD; cd02344; ZZ_HERC2; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 3.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR004939; APC_su10/DOC_dom.
DR   InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR   InterPro; IPR021097; CPH_domain.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR037976; HERC2_APC10.
DR   InterPro; IPR010606; Mib_Herc2.
DR   InterPro; IPR037252; Mib_Herc2_sf.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR014722; Rib_uL2_dom2.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   InterPro; IPR041987; ZZ_HERC2.
DR   PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR   PANTHER; PTHR22870:SF437; X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-RELATED; 1.
DR   Pfam; PF03256; ANAPC10; 1.
DR   Pfam; PF11515; Cul7; 1.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF06701; MIB_HERC2; 1.
DR   Pfam; PF00415; RCC1; 17.
DR   Pfam; PF00569; ZZ; 1.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM01337; APC10; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00706; TECPR; 5.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF159034; Mib/herc2 domain-like; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 4.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
DR   PROSITE; PS51284; DOC; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS51416; MIB_HERC2; 1.
DR   PROSITE; PS00626; RCC1_2; 1.
DR   PROSITE; PS50012; RCC1_3; 18.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00228}.
FT   REPEAT          459..514
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          515..566
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          569..620
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          621..672
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          1150..1226
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50255"
FT   DOMAIN          1802..1875
FT                   /note="MIB/HERC2"
FT                   /evidence="ECO:0000259|PROSITE:PS51416"
FT   DOMAIN          2646..2698
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   DOMAIN          2702..2879
FT                   /note="DOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51284"
FT   REPEAT          2902..2953
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          2954..3008
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          3009..3060
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          3061..3112
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          3115..3166
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          3167..3218
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          3219..3270
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          3895..3946
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          3947..4000
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4001..4052
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4053..4104
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4107..4158
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4159..4210
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4211..4262
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          4400..4737
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1498..1518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1876..1895
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3415..3440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3545..3572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4747..4777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4751..4765
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        4705
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   4777 AA;  520894 MW;  476E1B26C1DDFC5B CRC64;
     RSFARYPHDS VEQSGAKKED LNDKEKKDEE ETPAPVYRAK SILESWVWGK QPDVNELKEC
     LSVLVKEQQA LAVQSATTTL SALRLKQRLV ILERYFIALN RTVFQENVKV KWKSSSISLP
     PVDKKSCRPA GKGVEGLARV GSRAALSFAF AFLRRAWRSG EDADLCSELL QESLDALRAL
     PEASLFDEST VSSVWLEVVE RATRFLRSVV TGDVHGTPGT KGPGSIPLQD QHLALAILLE
     LAVQRGTLSQ MLSAILLLLQ LWDSGAQETD NERSAQGTSA PLLPLLQRFQ SIICSKDTPH
     SEGDMRLLSG PLSPNESFLR YLTLPQDNEL AIDLRQTAVV VMAHLDRLAT PCMPPLCSSP
     TSHKGSLQEV IGWGLIGWKY YANVIGPIQC EGLANLGVTQ IACAEKRFLI LSRNGRVYTQ
     AYNSDTLAPQ LVQGLASRNI VKIAAHSDGH HYLALAATGE VYSWGCGDGG RLGHGDTVPL
     EEPKVISAFS GKQAGKHVVH IACGSTYSAA ITAEGELYTW GRGNYGRLGH GSSEDEAIPM
     LVAGLKGLKV IDVACGSGDA QTLAVTENGQ VWSWGDGDYG KLGRGGSDGC KTPKLIEKLQ
     DLDVVKVRCG SQFSIALTKD GQVYSWGKGD NQRLGHGTEE HVRYPKLLEG LQGKKVIDVA
     AGSTHCLALT EDSEVHSWGS NDQCQHFDTL RVTKPEPAAL PGLDTKHIVG IACGPAQSFA
     WSSCSEWSIG LRVPFVVDIC SMTFEQLDLL LRQVSEGMDG SVDWPPPQEK ECMAVATLNL
     LRLQLHAAIS HQVDPEFLGL GLGSVLLNSL KQTVVTLASS AGVLGTVQSA AQAVLQSGWS
     VLLPTAEERA RALSALLPCA GNDVNISPGR RFMIDLLVGS LMADGGLESA LHAAITAEIQ
     DIEAKKEAQK EKEIDEQEAN ASTFHRSRTP LDKDLINTGI YESSGKQCLP LVQLIQQLLR
     NIASQTVARL KDVARRISSC LDFEQHSRER SASLDLLLRF QRLLISKLYP GESLGQTSDI
     SNPELMGVGS LLKKYTALLC THIGDILPVA ASVASTSWRH FAEVACIVEG DFTGVLLPEL
     VVSVVLLLSK NAGVMQEAGA VPLLGGLLEH LDRFNHLAPG KERDDHEELA WPGIMESFFT
     GQNCRNNEEV TLIRKADLEN HNKDGGFWTV IDGKVYDIKD FQTQSLTGNS ILAQFAGEDP
     VVALEAALQF EDTRESMHAF CVGQYLEPDQ EVVTIPDLGS LSSPLIDTER NLGLLLGLHA
     SYLAMSTPLS PVEIECAKWL QSSIFSGGLQ TSQIHYSYNE EKDEDHCSSP GGAPASKSRL
     CSHRRALGDH SQAFLQAVAD NNIQDHNVKD FLCQIERYCR QCHLTTPITF PPEHPVEEVG
     RLLLCCLLKH EDLGHVALSL VHAGALGIEQ VKHRTLPKSV VDVCRVVYQA KCSLIKTHQE
     QGRSYKEVCA PVIERLRFLF NELRPAVCND LSIMSKFKLL SSLPRWRRIA QKIIRERRRK
     RVPKKPESTD DEEKIGNEES DLEEACILPH SPINVDKRPI AIKSPKDKWQ PLLSTVTGVR
     RYKWLKQNVQ GLYPQSALLS TIAEFALKEE PVDVEKMRKC LLKQLERAEV RLEGIDTILK
     LASKNFLLPS VQYAMFCGWQ RLIPEGIDIG EPLTDCLKDV DLIPPFNRML LEVTFGKLYA
     WAVQNIRNVL MDANAKFKEL GIQPVPLQTI TNENPSGPSL GTIPQARFLL VMLSMLTLQH
     GANNLDLLLN SGTLALMQTT LRLIGPSCDN VEEDMNASAQ GASATVLEET RKETAPVQLP
     VSGPELAAMM KIGTRVMRGV DWKWGDQDGP PPGLGRVIGE LGEDGWIRVQ WDTGSTNSYR
     MGKEGKYDLK LAELPAAAQP SAEDSDTEDD SEAEQMERNI HPTAVMFTST INLLQTLCLS
     AGVHAELMQS EATKTLCGLL RMLVESGTTD KTSSPNRLVC REQHRSWCTL GFVRSIALTQ
     QVCGALSSPQ WITLLMKVVE GHAPFTAASL QRQILAVHLL QAVLPSWDKT ERARDMKCLV
     EKLFSFLGSL LTTCSSDVPL LRESTLRRRR ARPQASLTAT HSSTLAEEVV ALLRVLHSLT
     QWNGLINKYI NSQLRSITHS FAGRPSEGAQ LEDYFPNSEN PEVGGLMAVL AVIGGIDGRL
     RLGGQVMHDE FGEGTVTRIT PKGRITVQFS DMRMCRVCPL NQLKPLPAMA FNVNNLPFTE
     PMLSVWAQLV NLAGSKLEKH KIKKSTKQAF AGQVDLDLLR CQQLKLYILK AGRALLSHQD
     KLRQILSQPA VQETGTVHAD DGAVASPDLG DVSPEGPQPP MILLQQLLAS ATQPSPVKAI
     FDKQELEAAA LAVCQCLAVE STHPSSPGFE DCSSSEATTP VAVQHIRPAR VKRRKQSPVP
     ALPIVVQLME MGFPRRNIEF ALKSLTGASG NASGLPGVET LVGWLLDHSD VQVTELSDGD
     TVSDEYSDEE VMEDMDDAAY PVSTGAVVTE SQTFKKRADF LSNDDYAVYV RENIQVGMMV
     RCCRTYEEVC EGDVGKVIKL DRDGLHDLNV QCDWQQKGGT YWVRYIHVEL IGYPPPSSSS
     HIKIGDKVRV KSSVTTPKYK WGSVTHQSVG VVKAFSANGK DVIVDFPQQS HWTGLLSEME
     LVPSVHPGVT CDGCQMFPIN GSRFKCRNCD DFDFCETCFK TKKHNTRHTF GRINEPGQSA
     VFCGRSGKQL KRCHSSQPGM LLDSWSRMVK SLNVSSSVNQ ASRLIDGSEP CWQSSGSQGK
     HWIRLEIFPD VLVHRLKMIV DPADSSYMPS LVVVSGGNSL NNLIELKTIN INPSDTTVPL
     LNDCTEYHRY IEIAIKQCRS SGIDCKIHGL ILLGRIRAEE EDLAAVPFLA SDNEEEEDEK
     GSSGSLIRKK AAGLESTATI RTKVFVWGLN DKDQLGGLKG SKIKVPSFSE TLSALNVVQV
     AGGSKSLFAV TVEGKVYACG EATNGRLGLG ISSGTVPIPR QITALSSYMV KKVAVHSGGR
     HATALTVDGK VFSWGEGDDG KLGHFSRMNC DKPRLIEALK TKRIRDIACG SSHSAALTSS
     GELYTWGLGE YGRLGHGDNT TQLKPKMVKV LLGHRVIQVA CGSRDAQTLA LTDEGLVFSW
     GDGDFGKLGR GGSEGCNVPQ NIERLNGQGV CQIECGAQFS LALTKSGVVW TWGKGDYFRL
     GHGSDVHVRK PQVVEGLRGK KIVHVAVGAL HCLAVTDSGQ VYAWGDNDHG QQGNGTTTVN
     RKPTLVQGLE GQKITRVACG SSHSVAWTTV DVATPSVHEP VLFQTARDPL GASYLGVPSD
     ADSSAASNKI SGASNSKPNR PSLAKILLSL DGNLAKQQAL SHILTALQIM YARDAVVGSL
     MPAGMIAPVE CPSFSSAAPS DTSAVASPMN GEDCMLVLDI EDRLSPNPWQ EKREIVSSED
     AVTPSAVTPS APSASARPFI PVTDDPGAAS IIAETMTKTK EDVESQNKAA GPEPQALDEF
     TSLLIADDTR VVVDLLKLSV CSRAGDRGRE VLSAVLSGMG TAYPQVADML LELCVTELED
     VATDSQSGRL SSQPVVVESS HPYTDDTSTS GTVKIPGAEG LRVEFDRQCS TERRHDPLTI
     MDGVNRIVSV RSGREWSDWS SELRIPGDEL KWKFISDGSV NGWGWRFTVY PIMPAAGPKE
     LLSDRCVLSC PSMDLVTCLL DFRLNLASNR SIVPRLAASL AACAQLSALA ASHRMWALQR
     LRKLLTTEFG QSININRLLG ENDGEARTLS FTGSALAALV KGLPEALQRQ FEYEDPIVRG
     GKQLLHSPFF KVLVALACDL ELDTLPCCAE THKWAWFRRY CMASRVAVAL DKRTPLPRLF
     LDEVAKKIRE LMADSENMDV LHESHDVFKR EQDEQLVQWM NRRPDDWTLS AGGSGTIYGW
     GHNHRGQLGG IEGAKVKVPT PCEALATLRP VQLIGGEQTL FAVTADGKLY ATGYGAGGRL
     GIGGTESVSS PTLLESIQHV FIKKVAVNSG GKHCLALSSE GEVYSWGEAE DGKLGHGSRS
     PCDRPRVIES LRGIEVVDVA AGGAHSACVT AAGDLYTWGK GRYGRLGHSD SEDQLKPKLV
     EALQGHRVVD IACGSGDAQT LCLTDDDTVW SWGDGDYGKL GRGGSDGCKV PMKIDSLTGL
     GVVKVECGSQ FSVALTKSGA VYTWGKGDYH RLGHGSDDHV RRPRQVQGLQ GKKVIAIATG
     SLHCVCCTED GEVYTWGDND EGQLGDGTTN AIQRPRLVAA LQGKKVNRVA CGSAHTLAWS
     TSKPTSAGKL PAQVPMECNH LQEIPITALR NRLLLLHHIS ELLCPCIPMF DLEGWLDETG
     LGPSVGFDAL RGILISQGKE AAFRKVVQAT MVRDRQHGPV VELNRIQVKR SRSKGGLAGP
     DGTKSVFGQM CAKMSSFGPD SLLLPHRVWK VKFVGESVDD CGGGYSESIA EICEELQNGL
     TPLLIVTPNG RDESGANRDC YLLSPAARAP VHSSMFRFLG VLLGIAIRTG SPLSLSLAEP
     VWKQLAGMSL TIADLSEVDK DFIPGLMYIR DNEATSEEFE AMSLPFTVPS ASGQDIQLSS
     KHTHITLENR AEYVRLAINY RLHEFDEQVA AVREGMARVV PVPLLSLFTG YELETMVCGS
     PDIPLHLLKS VATYKGIEPS ASLIQWFWEV MESFSNTERS LFLRFVWGRT RLPRTIADFR
     GRDFVIQVLD KYNPPDHFLP ESYTCFFLLK LPRYSCKQVL EEKLKYAIHF CKSIDTDDYA
     RIALTGEPAA DDSSDDSDNE DVDSFASDST QDYLTGH
//

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