ID A0A2K5CKM1_AOTNA Unreviewed; 161 AA.
AC A0A2K5CKM1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transmembrane p24 trafficking protein 3 {ECO:0000313|Ensembl:ENSANAP00000009209.1};
GN Name=TMED3 {ECO:0000313|Ensembl:ENSANAP00000009209.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000009209.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000009209.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004151};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004151}.
CC Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004619}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004619}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003827}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC {ECO:0000256|ARBA:ARBA00007104, ECO:0000256|RuleBase:RU003827}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5CKM1; -.
DR Ensembl; ENSANAT00000027000.1; ENSANAP00000009209.1; ENSANAG00000022600.1.
DR GeneTree; ENSGT00940000159833; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF60; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003827};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..161
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014467200"
FT DOMAIN 32..114
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
SQ SEQUENCE 161 AA; 18187 MW; 2CE9D573AA27B317 CRC64;
MGCAAARSAS ALLLLLLLLG RALTFELPDN AKQCFHEEVE QGVKFSLDYQ VITGGHYDVD
CYVEDPQGNT IYRETKKQYD SFTHRAEVKG VYQFCFSNEF STFSHKTVYF DFQVGDEPPI
LPDMGNRVTA LTQVRAYWKQ LDNMQPGRTP VTEGLGQLTL S
//
