ID A0A2K5CM43_AOTNA Unreviewed; 809 AA.
AC A0A2K5CM43;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=G protein-coupled receptor 156 {ECO:0000313|Ensembl:ENSANAP00000009773.1};
GN Name=GPR156 {ECO:0000313|Ensembl:ENSANAP00000009773.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000009773.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000009773.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_012319343.1; XM_012463920.1.
DR RefSeq; XP_012319344.1; XM_012463921.1.
DR AlphaFoldDB; A0A2K5CM43; -.
DR STRING; 37293.ENSANAP00000009773; -.
DR Ensembl; ENSANAT00000027567.1; ENSANAP00000009773.1; ENSANAG00000022869.1.
DR GeneID; 105725010; -.
DR CTD; 165829; -.
DR GeneTree; ENSGT00940000159755; -.
DR OMA; THFCASQ; -.
DR OrthoDB; 5396723at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15292; 7tmC_GPR156; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR041946; GPR156_7TM.
DR PANTHER; PTHR10519:SF63; G-PROTEIN COUPLED RECEPTOR 156-RELATED; 1.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..312
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 422..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..389
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 422..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 88782 MW; 6653905D44045196 CRC64;
MEPEINCSEL CDSFSGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL GIVWTFLSCG
LLLILFFLAF TIRCRKNRIV KMSSPNLNIV TLLGSCLTYS SAYLFGIQDV LVGSSMETLI
QTRLSMLCVG TSLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALVMADVILL
MTWVLTDPIQ CLQILSVSMT VTGRDVSCTL TSTHFCASRY SDVWIALVWG CKGLLLLYGA
YLAGLTGHVS SPPVNQSLTI MVGVNLLVLA AGLLFIVTRY LHSWPNLVFG LMSGGIFVCT
TTINCFIFIP QLKQWKAFEE ENQTIRHMAK YFSTPSKRFH TQYGEEANCH LREEKSSMER
LLTEKNAVIE SLQEQVNNAK EKLVRLMSGE CTYDLPEGAA PPASSPSKDV QAIASVHSLA
ATQGPSGHLS DFQNDPSMAA QDSQCTSGPS SHAQRLEGPG KDISPSPGKE EKISDLKDFS
DRLDSSCSQK PWTEQRLGPE RGDQDPIAPS HSFLPGRGGS DPQRQRHLAE ELLERQLRVS
SVIREKLQEV LQDLGLGPEA SLPTLPSCHQ QPWRNSAAFS PPKMPLSKEP GFSPYMVRRR
RAAQRARSRF PGSAHSSVGH RANRTVSGVH SRLYVENGDS PSLAPQTADS RVQRPSSRKP
SLLSDSPGTL EGSKQSQTEP EGARGSEAAF LPQPSGSGQA PSPAAPCLSK ASPDLPEQWQ
LWPPVSSVCP SLSSRHSCFD TESSSSDEFF CRCHRPYCEI CFQSSSDSSD SCTSDTDSEP
TRGLASWEKL WARSSPIVNF KDDLKPTLV
//
