ID A0A2K5CMK5_AOTNA Unreviewed; 1383 AA.
AC A0A2K5CMK5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Collagen type IV alpha 3 chain {ECO:0000313|Ensembl:ENSANAP00000009935.1};
GN Name=COL4A3 {ECO:0000313|Ensembl:ENSANAP00000009935.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000009935.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000009935.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR Ensembl; ENSANAT00000027730.1; ENSANAP00000009935.1; ENSANAG00000022940.1.
DR GeneTree; ENSGT00940000161675; -.
DR OMA; KGPPGRC; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1077; COLLAGEN ALPHA-3(IV) CHAIN; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 14.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1201..1382
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 1..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..167
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..405
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..454
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..492
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1383 AA; 134078 MW; 50D682413E1A35C9 CRC64;
MGDRVIGQKG ERGVKGLTGP PGPPGTVIVT LTGPDNRTNL KGEKGDKGAM GEPGPPGPSG
LPGESYGSEK GAPGEPGPQG KPGRDGVPGF PGSEGVKGNR GFPGLTGEDG IKGQKGDIGP
PGFRGPTEYY DTYQEKGDKG IPGPPGPKGA RGPQGPSGPP GVPGSPGPSR PGLRGVPGWP
GLKGSKGERG PPGKDAMGTP GSPGCPGSPG PTGSPGPPGP PGDIVFRKGP PGDRGLPGYL
GSPGILGVDG PKGEPGLLCT QCPYIPGPPG LPGLPGLHGV KGIPGRQGAP GLKGSPGSPG
NTGLPGFPGF PGAQGDPGLK GEKGETLQPK GQVGAPGDPG LRGQPGRKGL DGIPGTPGVK
GLPGPKGELA LSGEKGDQGP PGDPGSPGFP GPAGPAGPPG YGPQGKPGPK GTQGVPGAPG
PPGEAGPRGE VSVSTPVPGP PGPPGAPGLA GPQGPPGIPG SMGKYGDPGL PGPDGEPGIP
GIGFPGPPGP KGDQGFPGTK GSLGCPGKMG EPGLPGKPGL PGAKGEPALA MPGGPGAPGF
PGERGNSGEH GEIGLPGLPG LPGTPGNEGL DGPRGDPGQP GPPGEQGPQG RCIEGPRGAQ
GLPGLNGLKG QQGRRGKTGP KGDPGIPGLD RSGFPGETGS PGRPGHQGET GPPGQKGYPG
NPGILGPPGE DGMVGMMGFP GAIGSPGPPG NPGMPGQRGS LGIPGVKGQR GTPGAKGEQG
DKGNPGPSQI SHLIGDKGEP GLKGFAGNVG EKGNRGVPGL PGLKGLQGLP GPPGPPGPRG
DLGSIGHPGE PGPRGVPGSM GNMGMPGSKG RRGTLGFPGR AGRPGLPGIH GLQGDKGEPG
YSEGTRPGPP GPTGDPGLPG DTGKKGEMGQ PGPPGHSGPA GPEGVIGSPG SPGLPGKPGP
HGDLGFKGIK GFLGPPGIKG PPGLPGFPGS PGPMGIRGDQ GHDGIPGPAG EKGETGLLGA
PPGPRGNPGA QGAKGDRGSP GLPGLPGRKG AMGDAGPRGP TGIEGFPGPP GLPGAIIPGQ
KGNRGPPGSR GRPGDPGPLG PPGSHVKGIK GDKGSMGHPG PKGPPGTVGD MGPPGHLGAP
GTPGLPGLRG DPGFRGFPGV KGEKGNPGFL GSIGPPGPIG PKGPPGIRGD PGTLQIISLP
GSPGPPGTPG EPGMRGEPGP PGPPGNLGPC GPRGKPGKDG KPGIPGPVGE KGNKGSKGEQ
GTLGSCLQRF TTMPFLFCNI NDVCNFASRN DYSYWLSTPA LMPMNMAPIT GRALEPYISR
CTVCEGPAIA IAVHSQTTDI PPCPHGWISL WKGFSFIMFT SAGSEGAGQA LASPGSCLEE
FRASPFLECH GRGTCNYYSN SYSFWLASLN PERMFRKPIP STMKAGELEK IVSRCQVCMK
KRQ
//
