ID   A0A2K5CQ09_AOTNA        Unreviewed;       278 AA.
AC   A0A2K5CQ09;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Calcium uptake protein 1, mitochondrial {ECO:0000256|ARBA:ARBA00040181};
GN   Name=MICU1 {ECO:0000313|Ensembl:ENSANAP00000010789.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000010789.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000010789.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC       space {ECO:0000256|ARBA:ARBA00004569}.
CC   -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00038333}.
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DR   AlphaFoldDB; A0A2K5CQ09; -.
DR   Ensembl; ENSANAT00000028593.1; ENSANAP00000010789.1; ENSANAG00000023282.1.
DR   GeneTree; ENSGT00950000183079; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IEA:InterPro.
DR   CDD; cd16173; EFh_MICU1; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR039800; MICU1/2/3.
DR   PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR   Pfam; PF13202; EF-hand_5; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          20..55
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          210..245
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
SQ   SEQUENCE   278 AA;  31975 MW;  E125EF4057ED5500 CRC64;
     MKRVYTCRLA KEIFKGTPKT PQRNFEIAFK MFDLNGDGEV DMEEFEQVQS IIRSQTSMGM
     RHRDRPTTGN TLKSGLCSAL TTYFFGADLK GKLTIKNFLE FQRKLQHDVL KLEFERHDPV
     DGRITERQFG GMLLAYSGVQ SKKLTTMQRQ LKKHFKEGKG LTFQEVENFF TFLKNINDVD
     TALSFYHVAG ASLDKVTMQQ VARTVAKVEL SDHVCDVVFA LFDCDGNGEL SNKEFVSIMK
     QRLMRGLEKP KDMGFTRLMQ AMWKCAQETA WDFALPKQ
//