ID A0A2K5CQZ1_AOTNA Unreviewed; 1783 AA.
AC A0A2K5CQZ1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSANAP00000011112.1};
GN Name=TSC2 {ECO:0000313|Ensembl:ENSANAP00000011112.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000011112.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000011112.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSANAT00000028918.1; ENSANAP00000011112.1; ENSANAG00000023148.1.
DR GeneTree; ENSGT00950000183139; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 1507..1734
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1742..1766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1742..1760
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1783 AA; 198252 MW; F5A63497965A5685 CRC64;
MAKPTSKDSG LKEKFKNLLG LGTPRPNPRS AEGKQTEFII TAEVLRELSV ECGLNNRIRM
IGQICEVAKT KKFEEHAVEA LWKAVADMLQ PERPLEARHA VLALLKAIVQ GQGERLGILR
ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL ADFVLQWMDV GLSSEFLLVL
VNLVKFNSCY LDEYIARMVQ MICLLCVRTA SSVDIEVSLQ VLDAVVCYNC LPAESLPVFI
VTLCRTINVK ELCEPCWKLM RNLLGTHLGH SAIYNMCHLM EDRAYMEDAP LLRGAVFFVG
MALWGAHRLY SLRNSPTSVL PSFYQAMACA NEVVSYEIVL SITRLIKKYR KELQAVTWDI
LLNIIERLLQ QLQTLDSLEL RTIVHDLLTT VEELCDQNEF HGSQERYFEL VERCADQRPE
SSLLNLISYR AQSIHPAKDG WIQNLQALME RFFRSESRGA VRIKVLDVLS FVLLINRQFY
EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMTRSLS
PPPELEERDV AAYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYEML VSHIQLHYKH
NYTLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCVCDYME PERGSEKKAS
GSLSPPTGPS GPTPAGPAVR LGSLPYSLLF RVLLQCLKQE TDWKVLKLVL GRLPESLRYK
VLIFTSPCSV DQLCSALCSM LSGPKTVERL RGAPEGFSRT DLHLAVVPVL TALISYHNYL
DKTKQREMVY CLEQGLVHRC ASQCVVALSI CSVEMPDIII KALPVLVVKL THISATASMA
VPLLEFLSTL ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
RLPFRKDFVP FITKGLRSNV LLSFDDTPEK DSFRARSTSL NERPKSLRIA RPPKQGLNNS
PPVKEFKESS AAEAFRCRSI SVSEHVVRRI QTSLTSASLG SADENSVAQA DDSLKNLHLE
LTETCLDMMA RYVFSNFTAV PKRSPVGEFL LAGGRTKTWL VGNKLVTVTT SVGTGTRSLL
GLDSGELQAG PELSSSPGVH VRQTKEAPAK LESQAGQQVS RGARDRVRSM SGGHGLRVGT
LDVPPSQFLG SATSPGPQTA PATKPEKASA STRVPVQEKT NLAAYVPLLT QGWAEILVRR
PTGNTSWLMS LENPLSPFSS DINSMPLQEL SNALMAAERF KEHRDTALYK SLSVPAASTA
KPPPLPRSNT DSAVVMEEGS PGEVPAPVEP PELEDFEAAL GADRRMDTYS RSSSTSSQEE
KSFHAEELVA RGIPIERAVS SESGRPSVDL SFQPSQPLSK SSSSPELQTL QDILGDPGDK
AEVGRLSPEV KARSQSGILD GDSATWSAPG EDSRGQPEGP LPSSSPRSPS GLRPRGYTIS
DSAPSRRGKR VERDAFKSRA AASNAEKVPG INPSFVFLQL YHSPFFGDES NKPILLPNES
QSFERSVQLL DQIPSYDTHK IAVLYVGEGQ SNSELAILSN EHGSYRYTEF LTGLGRLIEL
KDCQPDKVYL GGLDVCGEDG QFTYCWHDDI MQAVFHIATL MPTKDVDKHR CDKKRHLGND
FVSIVYNDSG EDFKLGTIKG QFNFVHVIIT PLDYECNLVS LQCRKDMEGL VDTSVAKIVS
DRNLSFVARQ MALHANMASQ VHHSRSNPTD IYPSKWIARL RHIKRLRQRI CEEAPYSNPS
LPVVHPPAHA KAPAPTPAEP TPGYEMGQRK RLISSVEDFT EFV
//
