ID   A0A2K5CTY6_AOTNA        Unreviewed;      1117 AA.
AC   A0A2K5CTY6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Ubiquitin specific peptidase 28 {ECO:0000313|Ensembl:ENSANAP00000012164.1};
GN   Name=USP28 {ECO:0000313|Ensembl:ENSANAP00000012164.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000012164.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000012164.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012325910.1; XM_012470487.1.
DR   AlphaFoldDB; A0A2K5CTY6; -.
DR   STRING; 37293.ENSANAP00000012164; -.
DR   Ensembl; ENSANAT00000029983.1; ENSANAP00000012164.1; ENSANAG00000024006.1.
DR   GeneID; 105729600; -.
DR   CTD; 57646; -.
DR   GeneTree; ENSGT00940000157670; -.
DR   OrthoDB; 1423057at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   CDD; cd02665; Peptidase_C19I; 1.
DR   CDD; cd14355; UBA_UBP28; 1.
DR   CDD; cd20487; USP28_C; 1.
DR   Gene3D; 6.10.250.1720; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR24006:SF678; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 28; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF46934; UBA-like; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          140..628
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          39..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          675..708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          747..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          383..410
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        454..505
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..708
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        759..787
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1117 AA;  127160 MW;  EC1CBFCD7D0CAC7A CRC64;
     MLLNQLREIT GIQDPSFLHE ALKASNGDIT QAVSLLTDER VKEPSQDTVA TEPSEVEGSA
     ANKEVLAKVI DLTHDNKDDL QAAIALSLLE SPKIQADGRD LNRMHEATSA ETKRSKRKRC
     EVWGENPNPN DWRRVDGWPV GLKNVGNTCW FSAVIQSLFQ LPEFRRLVLS YSLPQNVLEN
     CRSHTEKRNI MFMQELQYLF ALMMGSNRKF VDPSAALDLL KGAFRSSEEQ QQDVSEFTHK
     LLDWLEDAFQ LAVNVNSPRN KSENPMVQLF YGTFLTEGVR EGKPFCNNET FGQYPLQVNG
     YRNLDECLEG AMVEGDVELL PSDHLVKYGQ ERWFTKLPPV LTFELSRFEF NQSLGQPEKI
     HNKLEFPQII YMDRYMYRSK ELIRNKRECI RKLKEEIKVL QQKLERYVKY GSGPARFPLP
     DMLKYVIEFA STKPASESCP PESDTHMTLP LSSVHCSVPD QTSKESTSTE SSSQDVESTF
     SSPEDSQHKS KPLTSSRSSM EMPAQPAPRT VTDEEINFVK TCLQRWRSEI EQDIQDLKNC
     IASTTQTVEQ MYCDPLLRQV PYRLHAVLVH EGQANAGHYW AYIYNQPRQS WLKYNDISVT
     ESSWEEVERD SYGGLRNVSA YCLMYINDKL PHFNAEAAPN ESDQMSEVEA LSVELKHYIQ
     EDNWRFEQEV EEWEEEQSCK IPQMESSTNS SSQDFSTSQE PSVASSHGVR CLSSEHAVIV
     KEQTAQAIAN TARAYEKSGV EAALSELKEA EPKKPMPQET NLAEQSEQPQ KANDAESTAQ
     PNSEVSEVEI PSVGRILVRS DADGYDEEVM LSPAMQGVIL AIAKARQTFD RDGSEAGLIK
     AFHEEYSRLY QLAKETPTSH SDPRLQHVLV YFFQNEAPKR VVERTLLEQF ADKNLSYDER
     SISIMKVAQA KLKEIGPDDM NMEEYKKWHE DYSLFRKVSV YLLTGLELYQ KGKYQEALSY
     LVYAYQSNAA LLMKGPRRGV KESVIALYRR KCLLELNAKA ASLFETNDDL SVTEGINVMN
     ELIIPCIHLI INNDISKDDL DAIEIMRNHW CSYLGQDIAE NLQLCLGEFL PRLLDPSAEI
     IVLKEPPTIR PNSPYDLCSR FAAVMESIQG VSTVTVK
//