ID   A0A2K5CWK7_AOTNA        Unreviewed;      1342 AA.
AC   A0A2K5CWK7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Immunoglobulin superfamily member 1 {ECO:0000313|Ensembl:ENSANAP00000013072.1};
GN   Name=IGSF1 {ECO:0000313|Ensembl:ENSANAP00000013072.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000013072.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000013072.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 37293.ENSANAP00000013072; -.
DR   Ensembl; ENSANAT00000030894.1; ENSANAP00000013072.1; ENSANAG00000024439.1.
DR   GeneTree; ENSGT01100000263478; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038102; F:activin receptor antagonist activity; IEA:Ensembl.
DR   GO; GO:0034711; F:inhibin binding; IEA:Ensembl.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR   PANTHER; PTHR11738:SF159; PLATELET GLYCOPROTEIN VI; 1.
DR   Pfam; PF13895; Ig_2; 6.
DR   SMART; SM00409; IG; 9.
DR   SMART; SM00408; IGc2; 8.
DR   SUPFAM; SSF48726; Immunoglobulin; 12.
DR   PROSITE; PS50835; IG_LIKE; 6.
PE   4: Predicted;
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        520..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        551..579
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1267..1288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          38..106
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          321..392
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          419..484
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          782..874
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          878..947
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          1070..1139
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          1311..1342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1318..1336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1342 AA;  149812 MW;  CBC4D168F55A330E CRC64;
     VTLDRPGEGA TMLQTFTILL FCIRMSLGMT SIVMDLQPEL WIESNYPQAP WENITLWCRS
     PSRLSSKFLL LKDKTQMTWI HPSHKTFQVS FLLGALTEFN AGLYRCCYWK ETGWSKPSKI
     LELEAPGQLP KPIFWIQAET PPLRGCNVNI LCHGWLQDLV FMLFKEGYAE PVDYQVPTGT
     MAIFSIDNLT PEDEGVYVCR THIQMLPTLW SEPSNPLKLV VAGLYPKPTL TAHPGPIMAP
     GESLNLRCQG PIYGMTFALM RVEDLEKSFY HKKTIKNEAY FFFRSLKIQD TGHYLCFYYD
     GSYRGSLLSD VLKIWVTDTF PKTWLLARPS PVVQMGQNVS LRCQGQVDGV GLALYKKGED
     KPLQFLDATS IDDNTSFILN NVTYNDTGIY SCHYLLTWKT SIRMPSHNTV ELMVVDKPPK
     PSLSAWPSTV FKLGKAITLQ CRVSHPVLEF SLEWEERETF QKFSEDGDFI ISNVDGKGTG
     TYSCSYRIET QPDIWSHRSE PLKLMGPAGY LTWNYFLNEA IRLSLIMQLV ALLLVVLWIR
     WKCRRLRIRE AWLLGTAQGV TMLFIVTALL CCAISFAGLC NGVLTEETEI LMPTPKPELW
     AETNFPLAPW KNLTLWCRSP TGSTKEFVLL KDGTGWIATR PATAQVRAAF PLGALTQSHV
     GSYHCHSWEE MAVSEPSEAL ELVGTDILPK PVISASPPIR GKELQIQCKG WLAGMGFALY
     KEGKKEPVRQ LGAVGREAFF TIKRMEDKDE GNYSCRTHTA KRPFKWSEPS EPLELVIKEM
     YPKPFFKTWA SPVVTPGARV TFNCSTPHQH MSFILYKDGS EIASSDRSWA SPGASAAHFL
     ILSVGIGDGG NYSCRYYDFS IWSEPSDPVE LVVTEFYPKP TLLAQPGPVV FPGKNVTLRC
     QGNFQGMRFA LLQEGAQVPL QFRSASGNSA DFLLHTVGAE DSGNYSCIYY ETTMSNRGSY
     LSMPLMIWVT DTFPKPWLFA EPSSVVPMGQ NVTLWCQGPV PGVGYILHKE GGATSMQLWG
     STSNDGVFPI TNISAASMGR YSCCYHPDWT SSIKIQPSNT LELMVTGLLP KPSLLAQPGP
     MVAPGENMTL QCQGELPDST FVLLKKGTQE PLEQQKPSGY RADFWMPAVR GEDSGIYSCV
     YYLDSAPFAA SYHSDSLEVW VTDKPPKPSL SAWPSTMFKL GKDITLQCRG PLPGVEFVLE
     HDGEEAPQQF SEDGDFVINN AEGKGIGNYS CSYRLQAYPD IWSEPSDPLE LVGAAGPLAQ
     ECTVGNIVRS TLIVVVVVAL GVVLAVEWKK WPRLRTRRSE MDGRDQTIAL EECNQEEGEP
     GTPTNSSSSS SQRFSLELPV PI
//