ID   A0A2K5CX36_AOTNA        Unreviewed;       659 AA.
AC   A0A2K5CX36;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 {ECO:0000313|Ensembl:ENSANAP00000013260.1};
GN   Name=APPL1 {ECO:0000313|Ensembl:ENSANAP00000013260.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000013260.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000013260.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
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DR   AlphaFoldDB; A0A2K5CX36; -.
DR   Ensembl; ENSANAT00000031082.1; ENSANAP00000013260.1; ENSANAG00000024528.1.
DR   GeneTree; ENSGT00940000156624; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd13247; BAR-PH_APPL; 1.
DR   CDD; cd07631; BAR_APPL1; 1.
DR   CDD; cd13158; PTB_APPL; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR047181; DP13A/B.
DR   InterPro; IPR037929; DP13A_BAR.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR047236; PH_DP13A/B.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR047237; PTB_APPL.
DR   PANTHER; PTHR46415; ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2; 1.
DR   PANTHER; PTHR46415:SF3; DCC-INTERACTING PROTEIN 13-ALPHA; 1.
DR   Pfam; PF16746; BAR_3; 1.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          482..615
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          385..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..399
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..645
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   659 AA;  73899 MW;  3F7F60BFBDC20C70 CRC64;
     MPGIDKLPIE ETLEDSPQTR SLLGVFEEDA TAISNYMNQL YQAMHRIYDA QNELSAATHL
     TSKLLKEYEK QRFPLGGDDE VMSSTLQQFS KVIDELSSCH AVLSTQLADA MMFPITQFKE
     RDLKEILTLK EVFQIASNDH DAAINRYSRL SKKRENDKVK YEVTEDVYTS RKKQHQTMMH
     YFCALNTLQY KKKIALLEPL LGYMQAQISF FKMGSENLNE QLEEFLANIG TSVQNVRREM
     DSDVETMQQT IEDLEVASDP LYVPDPDPTK FPVNRNLTRK AGYLNARNKT GLVSSTWDRQ
     FYFTQGGNLM SQARGDVAGG LAMDIDNCSV MAVDCEDRRY CFQITSFDGK KLWICTINNI
     SKQIYLSENP EETAARVNQS ALEAVTPSPS FQQRHESLRP AGGQSRPLTA RTSSSGSLGS
     ESTNLAALSL DSLVAPDTPI QFDIISPVCE DQPGQAKASG QGGSVFYSFG KEIWYSILHQ
     LFIVRFLGSM EVKSDDHPDV VYETMRQILA ARAIHNIFRM TESHLLVTCD CLKLIDPQTQ
     VTRLTFPLPC VVLYATHQEN KRLFGFVLRT SGGRSESNLS SVCYIFESNN EGEKICDSVG
     LAKQIALHAE LDLEEQSRLI AASSRPNQAS SEGQFVVLSS SQSEESDLGE EGKKRESEA
//