ID A0A2K5CX63_AOTNA Unreviewed; 480 AA.
AC A0A2K5CX63;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=CASP8 and FADD like apoptosis regulator {ECO:0000313|Ensembl:ENSANAP00000013283.1};
GN Name=CFLAR {ECO:0000313|Ensembl:ENSANAP00000013283.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000013283.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000013283.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
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DR RefSeq; XP_012301599.1; XM_012446176.1.
DR AlphaFoldDB; A0A2K5CX63; -.
DR STRING; 37293.ENSANAP00000013283; -.
DR Ensembl; ENSANAT00000031105.1; ENSANAP00000013283.1; ENSANAG00000024537.1.
DR GeneTree; ENSGT00530000064199; -.
DR OMA; NCFRSIH; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0031264; C:death-inducing signaling complex; IEA:Ensembl.
DR GO; GO:0097342; C:ripoptosome; IEA:Ensembl.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0060544; P:regulation of necroptotic process; IEA:Ensembl.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..73
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 92..170
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 263..358
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 480 AA; 55538 MW; 3BA8E70EDB2B39BC CRC64;
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDVLRERGKL SAVSLAELLY
RVRRFDLLKR ILKMDRKFVE DQLLRHPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMRDYM
GRGKINKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RLDLKTKIQK YKQSAQGART
SYKKVLQGAI ENSFKDPSNN FRLHNGRSKE QRLKEQLGTQ QEPVKTSIQE SETFLPQSIP
EERYKMKSKP LGICLIIDCI GSETELLRDT FTSLGYEVQK SLHLTMDGIL DVLQRVACMP
QHQDYDSFVC VLVSRGGSRS VYGVDRTHSG LPLHHIRRMF MGDLCPYLVG KPKVFFIQNY
MVSEGQLEDS SVLEVDGPAM KNVESKPQQR GLYTVHREAD FFWSLCTADV SLLERSCSSP
SLYLQCLSQK LRQERKRPLL DLHIELNSHM YDWNSRVSAK EKYDVWLQHT LRKKLILSYT
//
