ID A0A2K5CYR2_AOTNA Unreviewed; 2068 AA.
AC A0A2K5CYR2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSANAP00000013833.1};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSANAP00000013833.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000013833.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000013833.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_012314086.1; XM_012458663.1.
DR Ensembl; ENSANAT00000031661.1; ENSANAP00000013833.1; ENSANAG00000024717.1.
DR GeneID; 105721568; -.
DR CTD; 23348; -.
DR GeneTree; ENSGT00940000155972; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 173..280
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 639..817
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1604..2068
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 289..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2068 AA; 236561 MW; C7628FFD64376012 CRC64;
MQADKCRTSS RSVKKELVIE SPLQYKDAAQ VEVEAESPGP VPAKPKLIEP LDYENVIVQK
KTQILNDCLR EMLLFPYDDF QTAILRRQGR YICSTVPAKA EEEAQSLFVT ECIKTYNSDW
HLVNYKYEDY SGEFRQLPNK VVKLDKLPVH VYEVDEEVDK DEDAASLGSQ KGGITKHGWL
YKGNMNSAIS VTMRSFKRRF FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN
NKVRRFAFEL KMQDKSSYLL AADSEVEMEE WITILNKILQ LNFEAAMQEK RNGDSHEDDE
QSKLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFL SAEPEVKPFE
EKFGKRILVK CNDLFFNLQC CVAENEEGPT TNVEPFFVTL SLFDIKYNRK ISADFHVDLN
HFSVRQMLAT ASPAVMNGSG QSPSVLKGIL HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK
VLQGSITHCA EPYMKSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD
KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDN VSSDFPNYVN
SSYIPTKQFE TCSKTPITFE VEEFVPCIPK HTQPYTIYTN HLYVYPKYLK YDSQKSFAKA
RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSAFAAV LHHHQNPEFY DEIKIELPTQ
LHEKHHLLLT FFHVSCDNSS KGSTKKRDVV ETQVGYSWLP LLKDGRVVTS EQHIPVSANL
PAGYLGYQEL GMGRHYGPEI KWVDGGKPLL KISTHLVSTV YTQDQHLHNF FQYCQKTESG
AQALGNELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV TRVIIHVVAQ
CHEEGLESHL RSYVKYAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL TSNKLLKYSW
FFFDVLIKSM AQHLIENSKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK FRDNPEASKN
ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEFKFEFLRV VCNHEHYIPL
NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE VRLIAISVLK
NLLIKHSFDD RYASRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN AGMTVKDESL
ALPAVNPLVT PQKGNTLDNS LHKDLLGAIS GIASPYTTST PNINSVRNAD SRGSLISTDS
GNSLPERNSE KSNSLDKHQQ SSTLGNSVVR CDKLDQSEIK SLLMCFLYIL KSMSDDALFT
YWNKASTSEL MDFFTISEVC LHQFQYMGKR YIARTGMMHA RLQQLGSLDN SLTFNHSYGH
SDADVLHQSL LEANIATEVC LTALDTLSLF TLAFKNQLLA DHGHNPLMKK VFDVYLCFLQ
KHQSETALKN VFTALRSLIY KFPSTFYEGR ADMCAALCYE ILKCCNSKLS SIRTEASQLL
YFLMRNNFDY TGKKSFVRTH LQVIISVSQL IADVVGIGGT RFQQSLSIIN NCANSDRLIK
HTSFSSDVKD LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY SLAKSYASTP ELRKTWLDSM
ARIHVKNGDL SEAAMCYVHV TALVAEYLTR KEAVQWEPPL LPHSHSACLR RSRGGMFRQG
CTAFRVITPN IEEEASMMED VGMQDVHFNE DVLMELLEQC ADGLWKAERY ELIADIYKLI
IPIYEKRRDF ERLAHLYDTL HRAYSKVTEV MHSGRRLLGT YFRVAFFGQA AQYQFTDSET
DVEGFFEDED GKEYIYKEPK LTPLSEISQR LLKLYSDKFG SENVKMIQDS GKVNPKDLDS
KYAYIQVTHV IPFFDEKELQ ERKTEFERSH NIRRFMFEMP FTQTGKRQGG VEEQCKRRTI
LTAIHCFPYV KKRIPVMYQH HTDLNPIEVA IDEMSKKVAE LRQLCSSAEV DMIKLQLKLQ
GSVSVQVNAG PLAYARAFLD DTNTKRYPDN KVKLLKEVFR QFVEACGQAL AVNERLIKED
QLEYQEEMKA NYREMAKELS EIMHEQLG
//
