ID A0A2K5CZ43_AOTNA Unreviewed; 876 AA.
AC A0A2K5CZ43;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5B {ECO:0000313|Ensembl:ENSANAP00000013936.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000013936.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000013936.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR RefSeq; XP_012315716.1; XM_012460293.1.
DR AlphaFoldDB; A0A2K5CZ43; -.
DR Ensembl; ENSANAT00000031766.1; ENSANAP00000013936.1; ENSANAG00000024842.1.
DR GeneID; 105722644; -.
DR CTD; 219699; -.
DR GeneTree; ENSGT00950000182815; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF6; NETRIN RECEPTOR UNC5B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 22..876
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5025088750"
FT TRANSMEM 305..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 92..173
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 474..617
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 876 AA; 96021 MW; D3A17D31D2DE4601 CRC64;
MTHHLCILEM TLAARWSTLD GAEGLCQPLQ YAGLRVREVQ IEVSRQQVEE LFGLEDYWCQ
CVAWSSAGTT KSRRAYVRIA YLRKNFDQEP LGKEVPLDHE VLLQCRPPEG MPMAEVEWLK
NEDVIDPTQD TNFLLTIDHN LIIRQARLSD TANYTCVAKN IVAKRRSTTA TVTVYVNGGW
SSWAEWSPCS NRCGRGWQKR TRTCTNPTPL NGGAFCEGQA FQKTACTTVC PVDGAWTEWS
KWSACSTECA HWRSRECMAP PPQNGGRDCS GTLLDSKNCT DGLCMQNKKT LSDPNSHLLE
ASGDAALYAG LVVAIFVVVA VLMAVGVVVY RRNCHDFDTD ITDSSAALTG GFHPVNFKTA
RPSNPQLLHP SVPPDLTASA GIYRGPVCAL QDSTDKILMT NSPLLDSLPS LKVKVYSSST
TGSGQGLADG ADLLGVLPPG TYPSDFTRDS HFLHLRSASL GSQQLLGLPR DPGSSVSGTF
GCLGGRLSIP GTGVSLLVPN GAIPQGKFYE MYLLINKAEN TLPLSEGTQT VLSPSVTCGP
AGLLLCRPVI LTMPHCAEVS AGDWIFQLKT QAHQGHWEEV VTLDEETLNT PCYCQLEPRA
CHILLDQLGT YVFTGESYSR SAVKRLQLAV FAPALCTSLE YSLRVYCLED TPVALKEVLE
LERTLGGYLV EEPKPLVFKD SYHNLRLSLH DLPHAHWRSK LLAKYQEIPF YHIWSGSQKA
LHCTFTLERH SLASTELTCK ICVRQVEGEG QIFQLHTTLA ETPAGSLDTL CSAPGGAITT
QLGPYAFKIP LSIRQKICNS LDAPNSRGND WRMLAQKLSM DRYLNYFATK VSPTGVILDL
WEALQQDDGD LNSLASALEE MGKSEMLVAV ATDGDC
//