ID A0A2K5CZW9_AOTNA Unreviewed; 1565 AA.
AC A0A2K5CZW9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Adhesion G protein-coupled receptor B1 {ECO:0000313|Ensembl:ENSANAP00000014233.1};
GN Name=ADGRB1 {ECO:0000313|Ensembl:ENSANAP00000014233.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000014233.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000014233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 37293.ENSANAP00000014233; -.
DR Ensembl; ENSANAT00000032064.1; ENSANAP00000014233.1; ENSANAG00000025001.1.
DR GeneTree; ENSGT00940000157432; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
DR CDD; cd15990; 7tmB2_BAI1; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF39; ADHESION G PROTEIN-COUPLED RECEPTOR B1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 5.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1565
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014408993"
FT TRANSMEM 936..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1000..1018
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1039..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1078..1101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1122..1144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 563..633
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 934..1175
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 310..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1488..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1399..1425
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1565 AA; 171831 MW; BAB31C81C120F089 CRC64;
MRGQAAAPGP VWILAPLLLL LLGRRARAAA GADTGLVPEP CATLVQGKFF GYFSAAAVFP
ANASRCSWTL RNPDPRRYTL YMKVAKAPVP CAGPGRVRTY QFDSFLESTR TYLGVESFDD
VLRLCDSSAP LAFLQASKQF LQMRRQQPPR DGDLGPRAVP AGPGDDFSVE YLVVGNRSPS
RAACQMLCRW LDACLAGSRS SHPCGIMQTP CACLGGEAGG PAAGPLAPNG DVCLRDALAG
GPENCLTSLT QDRGGHGTTG GWKLWSLWGE CTRDCGGGLQ TRTRTCLPAQ GVEGGSCEGV
LEEGRQCNSE ACGPAGRTSS RSQSLRSTDA RRREELGDEL QHFGFPAPQT GDPAAEEWSP
WSVCSSTCGE GWQTRTRFCV SSSYSTQCSG PLREQRLCNN SAVCPVHGAW DEWSPWSLCS
STCGRGFRDR TRTCRPPQFG GNPCEGPEKQ TKFCNIALCP VDGNWNEWSS WSACSASCSQ
GRQQRTRECN GPSYGGAECQ GHWVETRDCF LQQCPVDGKW QAWASWGSCS VTCGAGSQRR
ERVCSGPFFG GTACQGPHDE YRQCGTQRCP EPHEICDEDN FGAVIWKETP AGEVAAVRCP
RNATGLILRR CELDEEGIAY WEPPTYIRCV SIDYRNIQMM TREHLAKAQR GLPGEGVSEV
IQTLVEISQD GTSYSGDLLS TIDVLRNMTE IFRRAYYSPT PGDVQNFVQI LSNLLAEENR
EKWEEAQLAG PNAKELFRLV EDFVDVIGFR MKDLRDAYQV TDNLVLSIHK LPASGATDIS
FPMKGWRATG DWAKVPEDRV TVSKSVFSTG LAEADEASVF VVGTVLYRNL GSFLALQRNT
TVLNSKVISV TVKPPPRSLR TPLEIEFAHM YNGTTNQTCI LWDETDQLGP WSWRGCRTVP
LDALRTRCLC DRLSTFAILA QLSADANMEK ATLPSVTLIV GCGVSSLTLL MLVIIYVSVW
RYIRSERSVI LINFCLSIIS SNALILIGQT QTRNKVVCTL VAAFLHFFFL SSFCWVLTEA
WQSYMAVTGH LRNRLIRKRF LCLGWGLPAL VVAISVGFTK AKGYSTMNYC WLSLEGGLLY
AFVGPAAAVV LVNMVIGILV FNKLVSKDGI TDKKLKERAG ASLWSSCVVL PLLALTWMSA
VLAVTDRRSA LFQILFAVFD SLEGFVIVMV HCILRREVQD AVKCRVVDRQ EEGNGDSGGS
FQNGHAQLMT DFEKDVDLAC RSVLNKDIAA CRTATITGTL KRPSLPEEEK LKLAHAKGPP
TNFNSLPANV SKLHLHGSPR YPGGPLPDFP NHSLTLKRDK APKSSFVGDG DIFKKLDSEL
SRAQEKALDT SYVILPTATA TLRPKPKEEA KYSIHIDQMP QTRLIHLSTA PDAGLPARSP
PSRQPPRPAA TRGIHHYPAL PPPQQPLPPP PSLEPAPPSL GEPGEPAAHP GPSAGPSTKN
ENVTTLSVSS LERRKSRYAE LDFEKIMHTR KRHQDMFQDL NRKLQHAVEK DKEVLGPESK
PEKQQTPNKR PWESLRKAHG TPTWVKKELE PLQPSPLELR SVEWERSGAT IPLVGQDIID
LQTEV
//
