ID A0A2K5D0F3_AOTNA Unreviewed; 1179 AA.
AC A0A2K5D0F3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Euchromatic histone lysine methyltransferase 2 {ECO:0000313|Ensembl:ENSANAP00000014423.1};
GN Name=EHMT2 {ECO:0000313|Ensembl:ENSANAP00000014423.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000014423.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000014423.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5D0F3; -.
DR Ensembl; ENSANAT00000032256.1; ENSANAP00000014423.1; ENSANAG00000025041.1.
DR GeneTree; ENSGT00940000159459; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10533; SET_EHMT2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038034; SET_EHMT2.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT REPEAT 653..685
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 686..718
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 719..743
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 753..785
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 819..851
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 941..1004
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1007..1124
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..334
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 128571 MW; 37FD564509B724F7 CRC64;
MAAAAGAAAA AAAEGEAPAE MGALLLEKET RGATERVHGS LGDTPRSEET LPKATPDSLE
PAGPSSPASV TVTVGDEGAD TPVGATPLIG DEPENLEGDG DLHGGRILLG HATKSFPSSP
SKGGSCPSRA KMSMTGAGKS PPSVQSLAMR LLSMPGAQGT AAAGPEPPPA TTSPEGQPKV
HRARKTMSKP GNGQPPVPEK RPPEVQHFRM SDDVHSLGKV TSDVAKRRKL NSGGGLSEEL
GSARRSGEVT LAKGDPGSLE EWETVVGDDF SLYYDSYSVD ERVDSDSKVR QRFLSTPPPP
PQSGSSGRRK AKKKWRKDSP WVKPSRKRRK REPPRAKEPR GVNGVGSSGP SEYMEVPLGS
LELPSEGTLS PNHAGVSNDT SSLETERGFE ELPLCSCRME APKIDRISER AGHKCMATES
VDGELSGCNA AILKRETMRP SSRVALMVLC ETHRARMVKH HCCPGCGYFC TAGTFLECHP
DFRVAHRFHK ACVSQLNGMV FCPHCGEDAS EAQEVTIPRG DGVTPPAGTA APAPPPLSQD
APGRADTSQP SARMRGHGEP RRPPCDPLAD TIDSSGPSLT LPNGGCLSAV GLPLGPGREA
LEKALVIQES ERRKKLRFHP RQLYLSVKQG ELQKVILMLL DNLDPNFQSD QQSKRTPLHA
AAQKGSVEIC HVLLQAGANI NAVDKQQRTP LMEAVVNNHL EVARYMVQRG GCVYSKEEDG
STCLHHAAKI GNLEMVSLLL STGQVDVNAQ DSGGWTPIIW AAEHKHIEVI RMLLTRGADV
TLTDNEENIC LHWASFTGSA AIAEVLLNAR CDLHAVNYHG DTPLHIAARE SYHDCVLLFL
SRGANPELRN KEGDTAWDLT PERSDVWFAL QLNRKLRLGV GNRAIRTERI ICRDVARGYE
NVPIPCVNGV DGEPCPEDYK YISENCETST MNIDRNITHL QHCTCVDDCS SSNCLCGQLS
IRCWYDKDGR LLQEFNKIEP PLIFECNQAC SCWRNCKNRV VQSGIKVRLQ LYRTAKMGWG
VRALQTIPQG TFICEYVGEL ISDAEADVRE DDSYLFDLDN KDGEVYCIDA RYYGNISRFI
NHLCDPNIIP VRVFMLHQDL RFPRIAFFSS RDIRTGEELG FDYGDRFWDI KSKYFTCQCG
SEKCKHSAEA IALEQSRLAR LDPHPELLPE LSSLPPVNT
//
