ID A0A2K5D0Y8_AOTNA Unreviewed; 327 AA.
AC A0A2K5D0Y8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sodium/bile acid cotransporter {ECO:0000256|PIRNR:PIRNR026166};
GN Name=SLC10A7 {ECO:0000313|Ensembl:ENSANAP00000014613.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000014613.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000014613.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Does not show transport activity towards bile acids or
CC steroid sulfates. {ECO:0000256|PIRNR:PIRNR026166}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR026166}.
CC Endoplasmic reticulum membrane {ECO:0000256|PIRNR:PIRNR026166}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528,
CC ECO:0000256|PIRNR:PIRNR026166}.
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DR AlphaFoldDB; A0A2K5D0Y8; -.
DR Ensembl; ENSANAT00000032447.1; ENSANAP00000014613.1; ENSANAG00000025194.1.
DR GeneTree; ENSGT00390000011932; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640:SF5; SODIUM_BILE ACID COTRANSPORTER 7; 1.
DR PANTHER; PTHR18640; SOLUTE CARRIER FAMILY 10 MEMBER 7; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR026166};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR026166};
KW Ion transport {ECO:0000256|PIRNR:PIRNR026166};
KW Membrane {ECO:0000256|PIRNR:PIRNR026166, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Sodium {ECO:0000256|PIRNR:PIRNR026166};
KW Sodium transport {ECO:0000256|PIRNR:PIRNR026166};
KW Symport {ECO:0000256|PIRNR:PIRNR026166};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR026166}.
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 327 AA; 36070 MW; 7EE821F86A7EC9F6 CRC64;
MRLLERMRKD WFMIGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT
EELTSALVHL KLHLFIQIFT LAFFPAAIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS
AVILTKAVGG NEGIVITPLL LLLFLGSSSS VPFTSIFSQL FMTVVVPLII GQIVRRYIKD
WLERKKPPFG AISSSVLLMI IYTTFCDTFS NPNIDLDKFS LVLILVIIFS IQLSFMLLTF
IFSTRNNSGF TPADTVAIIF CSTHKSLTLG IPMLKIVFAG HEHLSLISVP LLIYHPAQIL
LGSVLVPTIK SWMVSRQKGV KLTRPTV
//
