ID A0A2K5D1U2_AOTNA Unreviewed; 1087 AA.
AC A0A2K5D1U2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DCC netrin 1 receptor {ECO:0000313|Ensembl:ENSANAP00000014913.1};
GN Name=DCC {ECO:0000313|Ensembl:ENSANAP00000014913.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000014913.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000014913.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000256|ARBA:ARBA00009588}.
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DR AlphaFoldDB; A0A2K5D1U2; -.
DR Ensembl; ENSANAT00000032747.1; ENSANAP00000014913.1; ENSANAG00000025332.1.
DR GeneTree; ENSGT00940000158867; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010560; Neogenin_C.
DR PANTHER; PTHR44170:SF8; NETRIN RECEPTOR DCC; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF06583; Neogenin_C; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 733..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..71
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 86..179
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 185..275
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 280..373
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 383..476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 481..577
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 582..679
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 761..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 119611 MW; CFC4CBC0DC99F830 CRC64;
MDIEFECTVS GKPVPTVNWM KNGDVVIPSD YFQIVGGSNL RILGVVKSDE GFYQCVAENE
AGNAQTSAQL IVPKPAIPSS SVLPSAPRDV VPVLVSSRFV RLSWRPPAEV KGNIQTFTVF
FSREGDNRER ALNTTQPGSL QLTVGNLKPE AIYTFRVVAY NEWGPGESSQ PIKVATQPEL
QVPGPVENLQ AVSTSPTSIL ITWEPPAYAN GPVQGYRLFC TEVSTGKEQN IEVDGLSYKL
EGLKKFTEYS LRFLAYNRYG PGVSTDDITV VTLSDVPSAP PQNVSLEVVN SRSIKVSWLP
PPSGTQNGFI TGYKIRHRKT TRRGEMETLE PNNLWYLFTG LEKGSQYSFQ VSAMTVNGTG
PPSNWYTAET PENDLDESQV PDQPSSLHVR PQTNCIIMSW TPPLNPNIVV RGYIIGYGVG
SPYAETVRVD SKQRYYSIER LESSSHYVIS LKAFNNAGEG VPLYESATTR SITDLSTPML
PPVGVQAVAL THDAVRVSWA DNSVPKNQKT SEVRLYTVRW RTSFSASAKY KSEDTTSLSY
TATGLKPNTM YEFSVMVTKN RRSSTWSMTA HATTYEAAPT SAPKDLTVIT REGKPRAVIV
SWQPPLEANG KITAYILFYT LDKNIPIDDW IMETISGDRL THQIMDLNLD TMYYFRIQAR
NSKGVGPLSD PILFRTLKVE HPDKMANDQG RHGDGGYWPV DTNLIDRSTL NEPPIGQMHP
PHGSVTPQKN SNLLVIIVVT VGVITVLVVV IVAVICTRRS SAQQRKKRAT HSVGKRKGSQ
KDLRPPDLWI HHEEMEMKNI EKPSGTDPAG RDSPIQSCQD LTPVSHSQSE TQLGSKSTSH
SGQDTEEAGS SMSTLERSLA ARRAPRAKLM IPMDAQSNNP AVVSAIPVPT LESAQYPGIL
PSPTCGYPHP QFTLRPVPFP TLSVDRGFGA GRTVNEGPTT QQPPMLPPSQ PEHSSSEEAP
SRTIPTACVR PTHPLRSFAN PLLPPPMSAI EPKVPYTPLL SQPGPTLPKT HVKTASLGLA
GKARSPLLPV SVPTAPEVSE ESHKPTEDSA NVRMEWVKQY EISSYPLFNY QHLHSMNIFL
GQPWLWV
//
