ID A0A2K5D290_AOTNA Unreviewed; 568 AA.
AC A0A2K5D290;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=HELP domain-containing protein {ECO:0000259|Pfam:PF03451};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000015074.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000015074.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR AlphaFoldDB; A0A2K5D290; -.
DR STRING; 37293.ENSANAP00000015074; -.
DR Ensembl; ENSANAT00000032910.1; ENSANAP00000015074.1; ENSANAG00000025431.1.
DR GeneTree; ENSGT00940000153887; -.
DR OMA; HIRIWES; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT TRANSMEM 72..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..92
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 291..332
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 374..415
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 420..461
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 568 AA; 62168 MW; 23964EE4847A784C CRC64;
MSSFGAGKTK EVIFSMEDGS VKMFLRGHPV PMLIPDELAP TYSLDTCSEL PSCQLKLDWV
YGYRSRDCRA NLYFLPTGEI VYFVASVAVL YSVEEQRQRH YLGHSDDIKC LAIHPDMVTI
ATGQVAGTTK EGKNGGNLLC AVDKSKDHML SVWDWAKETK VVDVKKHEKP KYVLCVTFLE
GGDVVTGDSG GNLYVWGKGG NHITQVVLGA HDGSLFGLCA LRDGTLVSGG GRDQRVVLWG
SDYSKLQEME VCEDFGPVRT VAEGHGDTLY MGTTRNSILQ GSIHTGFSLL VQGHVEELWG
LPAHPSRAQF VTCGQDKLVH LWSSETHHPL WSRIIEDPAR SAGFHPSGSV LDVGTVTGRW
LLLDTETHDL VAIHTDGNEQ ISVVSFSPDG AYLVVGSHDN LVYVYTVEQG GRKISHLGKC
SGHSSFITHL DWAQDSSCFV TNSGDYEILY WDPATCKQIT SADAVRNVEW VTATCVLGFG
VFGIWCEGVD GTDINAVAHS HDGKLLASAD DFGKVHLFSY PCCQPRALSH KYGGNSSHVT
DVAFLWDDSM ALTTRGKDTS VLQSWRLQ
//
